Alpha-1 Antitrypsin (Serum) Concentration
This test measures the amount of Alpha-1 Antitrypsin, a protein produced by the liver that helps protect the lungs from damage caused by enzymes released during inflammation. Low levels may increase your risk of lung diseases like emphysema.
["This test helps assess your risk for lung diseases linked to low Alpha-1 Antitrypsin levels."]
Key facts at a glance
- LOINC
- 14011-1
- Short code
- Deprecated PA IgA Bld-aCnc
- Synonyms
- Deprecated PA IgA Bld-aCnc
- Category
- hematology
- Sample
- whole-blood
- Container
- Lavender-top (EDTA)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- CPT
- 82784
- Specimen volume
- 3 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h
- Hemolysis max
- 0
- Lipemia max
- 0
- Icterus max
- 0
- TAT
- 4–24 hours
- Order
- routine
Why This Test Might Be Ordered
Your healthcare provider may recommend this test if you have a family history of lung diseases, such as chronic obstructive pulmonary disease (COPD) or emphysema, especially if they run in your family. It may also be used to monitor lung health in people with known genetic conditions affecting Alpha-1 Antitrypsin levels.
What to Expect Before the Test
No special preparation is needed. You may have a small needle inserted into your arm to draw blood. If you’re taking blood from your own arm, follow your healthcare provider’s instructions for safety and comfort.
What the Test Results Mean
Results are compared to a general reference range for healthy adults. Very low levels may indicate a genetic disorder, while very high levels could suggest liver disease or other conditions. Your provider will discuss these results with you in the context of your overall health.
Common Conditions Linked to Results
Low levels of Alpha-1 Antitrypsin are strongly linked to conditions like alpha-1 antitrypsin deficiency, which can cause lung diseases. High levels may be associated with liver disease or certain inflammatory conditions.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Alpha-1 antitrypsin deficiency is a genetic condition that can lead to lung diseases like emphysema and chronic bronchitis. Early diagnosis through blood tests can help manage symptoms and prevent progression. If you have a family history of lung disease or symptoms like persistent coughing, wheezing, or shortness of breath, this test may be important to check your risk.
Short name
Alpha-1 Antitrypsin (A1AT) Level
Frequently asked questions
What does a low Alpha-1 Antitrypsin level mean?
What if my results are high?
Can I prevent lung disease if my levels are low?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy