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Protein Serum Electrophoresis by Bromocresol Green (qualitative)

Published: August 9, 2026Updated: August 16, 2026

This test measures the different types of proteins in your blood serum using a technique called electrophoresis. It helps identify abnormalities in protein distribution, which can signal conditions like multiple myeloma, liver disease, or other disorders.

Quick summary

["This test helps doctors check for unusual protein patterns that may indicate health concerns."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
27258-3
Short code
Deprecated Prot SerPl-sCnc
Synonyms
Deprecated Prot SerPl-sCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order this test to diagnose or monitor conditions affecting protein levels in your blood. For example, it can help detect signs of multiple myeloma, where abnormal proteins accumulate, or liver/kidney diseases that alter protein synthesis or breakdown.

What to Expect Before the Test

No special preparation is needed. You’ll likely have a small needle inserted to draw blood from a vein, usually in your arm. The process is quick and usually painless. If you’re on blood thinners, let your provider know before the test.

What the Results Mean

Results show the distribution of proteins across different fractions (e.g., albumin, globulins). Abnormal patterns—such as spikes (e.g., monoclonal bands) or reduced albumin—may signal underlying health issues. Your provider will interpret results in the context of your symptoms and medical history.

Common Conditions Monitored

This test is used to screen for conditions like multiple myeloma (a cancer of plasma cells), Waldenström macroglobulinemia (a rare blood disorder), liver disease, or kidney disease. It may also help evaluate autoimmune diseases or infections.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: Protein electrophoresis is critical for identifying monoclonal gammopathies (abnormal protein spikes), which can be early signs of plasma cell disorders. Reduced albumin levels may indicate malnutrition, liver failure, or nephrotic syndrome. Globulin fractions can reflect immune system activity or chronic inflammation.

Short name

Serum Protein Electrophoresis (BCG)

Frequently asked questions

What does a ‘spike’ or ‘band’ on the test results indicate?
A spike or band typically suggests the presence of an abnormal protein, such as a monoclonal protein (e.g., from multiple myeloma). These can be confirmed with further testing, like immunofixation electrophoresis. Your doctor will discuss findings with you.
Can diet affect protein electrophoresis results?
Dietary changes alone won’t alter the protein pattern on this test, but they may influence overall protein levels indirectly. For example, protein-rich diets could affect albumin levels, but the electrophoresis pattern itself is more about protein distribution than total protein quantity.
How often should this test be repeated?
Frequency depends on your condition. If you have a known disorder like multiple myeloma, your doctor may schedule follow-ups every few months to monitor changes in protein patterns. If this is a screening test, results may be reviewed annually or as needed.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy