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Amylase (Pancreatic) in Serum or Plasma

Published: August 9, 2026Updated: August 17, 2026

This test measures the level of amylase, an enzyme produced primarily by the pancreas, which helps break down carbohydrates. High levels may indicate pancreatic inflammation or injury.

Quick summary

["Amylase levels can signal possible pancreatic issues or digestive problems."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
69126-1
Short code
Deprecated RF Pancreas Bx needle guide
Synonyms
Deprecated RF Pancreas Bx needle guide
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Critical range
0.5 N/A – —
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
rf
CPT
86430
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your doctor may order this test to investigate symptoms like abdominal pain, nausea, vomiting, or diarrhea that could suggest pancreatitis, pancreatic cancer, or other digestive disorders. It can also help diagnose conditions like acute pancreatitis, cystic fibrosis, or certain types of kidney disease.

What to Expect Before the Test

No special preparation is usually needed. You may fast for 8–12 hours before the test if instructed, but this is not always required. Bring any medications you’re taking to your appointment.

How the Test Is Performed

A blood sample is drawn from a vein, typically in your arm, using a small needle. The sample is sent to a lab where it is tested for amylase levels using an immunoassay or enzymatic method.

Possible Results and Interpretation

Results are compared to a general reference range, but individual ranges can vary. Elevated levels may indicate pancreatitis, pancreatic tumors, or other conditions affecting digestion. Lower-than-normal levels are less common but may occur in rare cases of pancreatic insufficiency.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Pancreatic Amylase

Frequently asked questions

What does a high amylase level mean?
High levels of pancreatic amylase often signal acute pancreatitis, which is a severe inflammation of the pancreas. It can cause severe pain, vomiting, and may require medical attention. Chronic elevations might suggest long-term pancreatic issues or other conditions like cystic fibrosis.
What does a low amylase level mean?
Low amylase levels are less frequently observed in standard tests but could indicate rare conditions affecting pancreatic function, such as chronic pancreatitis or certain genetic disorders. Your doctor will consider your symptoms and other test results for diagnosis.
How often should I get this test?
This test is typically ordered as needed, depending on your symptoms or medical condition. Your doctor may recommend follow-up testing if initial results are abnormal or if you have ongoing digestive or abdominal concerns.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy