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Prostate-Specific Antigen (PSA) Blood Test (Screening/Confirming)

Published: August 9, 2026Updated: August 16, 2026

This blood test measures levels of prostate-specific antigen, a protein produced by both normal and cancerous prostate cells. It helps assess prostate health and detect early signs of prostate cancer or other conditions.

Quick summary

["PSA tests are used to monitor prostate health and guide decisions about further evaluation."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
69228-5
Short code
Deprecated RF Prostate Bx needle guide
Synonyms
Deprecated RF Prostate Bx needle guide
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
rf
CPT
86430
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Doctors may order a PSA test to: check for signs of prostate cancer in men with no symptoms, monitor the progression or treatment response of prostate cancer, or evaluate symptoms like urinary issues that could indicate prostate problems. It is not a definitive cancer test but is part of a broader evaluation.

What to Expect Before the Test

No special preparation is needed. You may be asked to avoid ejaculation for 2–4 days before the test if you’ve had recent prostate exams. Bring any medications you’re currently taking, as some may affect results.

What Happens During the Test

A healthcare provider will draw blood from a vein in your arm. The process takes about 5 minutes and may cause a slight pinch. The sample is sent to a lab for analysis.

What the Results Mean

PSA levels vary by age, overall health, and other factors. A higher-than-normal level may signal prostate cancer or other conditions, but it does not confirm a diagnosis alone. Your doctor will interpret results in the context of your medical history and symptoms.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Elevated PSA levels can indicate prostate cancer, benign prostatic hyperplasia (BPH), prostatitis, or other prostate-related issues. While PSA screening has reduced prostate cancer deaths, it also leads to unnecessary biopsies and overdiagnosis. Discuss risks and benefits with your doctor before screening.

Short name

PSA Test

Frequently asked questions

What does a PSA test measure?
A PSA test measures the amount of prostate-specific antigen (PSA) in your blood. PSA is a protein produced by the prostate gland, and its levels can help assess prostate health.
How often should I get a PSA test?
The frequency depends on your age, risk factors, and doctor’s recommendation. The U.S. Preventive Services Task Force suggests against routine PSA screening for men aged 55–69 without symptoms. Discuss personalized timing with your healthcare provider.
Can PSA levels change with diet or exercise?
Dietary changes (e.g., high-fat foods) or exercise may have a *mild* impact on PSA levels, but the effect is usually small. Avoiding ejaculation for a few days before testing can help stabilize results.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy