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Alpha-1 Antitrypsin (A1AT) Serum Concentration

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of Alpha-1 Antitrypsin, a protein produced by the liver that helps protect the lungs and other organs from damage caused by enzymes released during inflammation.

Quick summary

["Alpha-1 Antitrypsin helps prevent lung and liver damage; low levels may indicate genetic disorders or chronic lung diseases."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
37603-8
Short code
Deprecated Ribs-L + Chest XR Lat+PA
Synonyms
Deprecated Ribs-L + Chest XR Lat+PA
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
xr
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms like chronic cough, shortness of breath, or unexplained liver issues. It’s also used to screen for or monitor Alpha-1 Antitrypsin deficiency, a genetic condition linked to lung diseases like emphysema or liver disorders.

What to Expect Before the Test

No special preparation is needed. You’ll have a small needle inserted into your arm to draw blood. It usually takes a few minutes, and you can resume normal activities afterward.

What the Results Mean

Results help determine if your Alpha-1 Antitrypsin levels are low or high. Low levels may suggest a genetic disorder, while very high levels could indicate liver disease or other conditions. Your provider will discuss findings in relation to your symptoms and medical history.

Common Conditions Linked to Results

Low Alpha-1 Antitrypsin levels are most strongly associated with Alpha-1 Antitrypsin deficiency, which can cause lung diseases (like emphysema) or liver cirrhosis. High levels may be seen in conditions like chronic hepatitis or certain liver cancers.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

This test is critical for diagnosing and managing Alpha-1 Antitrypsin deficiency, a hereditary condition that can lead to severe lung and liver disease if untreated. Early detection allows for better management and potential interventions to slow disease progression.

Short name

Alpha-1 Antitrypsin

Frequently asked questions

What causes abnormal Alpha-1 Antitrypsin levels?
Abnormal levels can result from genetic mutations (like Alpha-1 Antitrypsin deficiency), chronic liver disease, or certain infections. High levels may also occur with conditions like cirrhosis or hepatitis.
How often should I get this test?
Your provider will determine the frequency based on your symptoms, medical history, and risk factors. If you have a known deficiency, follow-up tests may be scheduled every few years or more often if symptoms develop.
Can diet or lifestyle changes affect Alpha-1 Antitrypsin levels?
Diet and lifestyle generally do not directly alter Alpha-1 Antitrypsin levels, but managing conditions like liver disease or smoking (which worsens lung issues) can indirectly impact overall health and symptoms related to the condition.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy