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Bilirubin (Total) in Serum/Plasma

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of bilirubin, a yellow pigment produced when your body breaks down old red blood cells.

Quick summary

["Helps assess liver function and detect conditions like jaundice or bile duct blockages."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
74738-6
Short code
Deprecated S anginosus gryB Bld Pos Ql Prb Mag
Synonyms
Deprecated S anginosus gryB Bld Pos Ql Prb Mag
Category
coagulation
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
probe-mag-capture
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why It Matters in Your Health

Bilirubin is a normal byproduct of red blood cell breakdown. When your liver struggles to process it, levels can rise, leading to yellowing of the skin or eyes (jaundice). High levels may signal liver disease, gallbladder issues, or other health concerns.

How the Test Works

Your blood sample is sent to a lab where bilirubin is measured using a chemical reaction that detects its presence. The result helps doctors diagnose conditions affecting your liver or bile flow.

Common Conditions Monitored

This test is often used to monitor liver function, detect jaundice in newborns, or investigate symptoms like dark urine, pale stools, or fatigue.

What to Expect Before the Test

No special preparation is needed, but avoid taking certain medications (like some pain relievers) that may affect results. Fasted or non-fasted blood draws are typically acceptable.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Elevated bilirubin often indicates liver disease, hemolysis (red blood cell destruction), or blockages in the bile ducts. Very low levels may rarely signal genetic disorders or liver problems. Your doctor will interpret results in context with your symptoms and medical history.

Short name

Total Bilirubin

Frequently asked questions

What causes bilirubin levels to rise?
Bilirubin levels can rise due to liver disease (e.g., hepatitis), bile duct blockages (e.g., gallstones), or conditions that destroy red blood cells faster than the liver can process them (e.g., anemia). Jaundice in newborns is also common and usually harmless.
How often should I get this test?
Your doctor will determine how often you need this test based on your symptoms, medical history, or ongoing conditions. Some people get it yearly, while others may need it more frequently if they have liver issues or other risk factors.
Can diet or supplements affect bilirubin levels?
Some foods (like high-fiber or cruciferous vegetables) or supplements (e.g., vitamin K) may indirectly affect liver function, but they rarely change bilirubin levels directly. Always discuss any changes with your healthcare provider.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy