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Serum/plasma probe for epidermal growth factor receptor (EGFR) mutation status (exon 20 insertion mutations)

Published: August 9, 2026Updated: August 16, 2026

This test checks for specific genetic changes in a protein called EGFR that may be linked to certain types of advanced lung cancer.

Quick summary

["Helps determine if a targeted cancer treatment might be effective for your condition."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
74746-9
Short code
Deprecated S epidermidis hsp60 Bld Pos Ql Prb Mag
Synonyms
Deprecated S epidermidis hsp60 Bld Pos Ql Prb Mag
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
probe-mag-capture
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your doctor may recommend this test if you have non-small cell lung cancer (NSCLC) that has spread or if it has certain genetic features. EGFR mutations are more common in people with adenocarcinoma, who smoke or have a history of smoking, or who live in areas with high pollution.

How the Test Works

A small sample of your blood is taken and analyzed using a specialized probe to detect specific genetic insertions in the EGFR gene. This process helps identify whether these mutations are present, which can guide treatment decisions.

What the Results Mean

Positive results indicate the presence of EGFR exon 20 insertion mutations, which may respond well to certain targeted therapies. Negative results mean these mutations are not detected in your sample.

Possible Treatments

If mutations are found, your doctor may recommend targeted drugs like EGFR tyrosine kinase inhibitors (TKIs). These treatments can be more effective for cancers with these genetic changes than standard chemotherapy alone.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

EGFR Mutation Probe (Exon 20 Insertion)

Frequently asked questions

This test is primarily used in advanced NSCLC to tailor treatment options based on genetic information, potentially improving response rates and survival outcomes.
This test is not typically done for routine screening or early-stage cancer detection. It’s usually ordered after initial diagnosis and further testing to guide advanced treatment planning.
What happens if my test results are positive?
A positive result means your cancer may respond better to specific targeted therapies. Your doctor will discuss these options with you, including potential benefits, side effects, and next steps in treatment planning.
Do I need to prepare for this test?
No special preparation is needed. Your blood sample is usually taken during a regular clinic visit. Avoid alcohol or strenuous activity before the test if advised by your doctor.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy