Serum Antigen Test for Alpha-1 Antitrypsin (A1AT) – Quantitative

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have a family history of alpha-1 antitrypsin deficiency, symptoms like chronic cough, wheezing, or liver issues, or if you’ve been diagnosed with conditions like emphysema or cirrhosis. It can also be used to monitor treatment progress or assess risk for complications.

What to Expect Before the Test

No special preparation is needed. You may have a blood sample drawn from a vein in your arm. If you’re taking blood thinners or have a history of bleeding disorders, let your provider know beforehand.

What the Test Results Mean

Results are compared to a standard range for healthy individuals. Low levels may indicate alpha-1 antitrypsin deficiency, while very high levels could suggest conditions like chronic inflammation or certain liver diseases. Your provider will discuss the results with you in the context of your overall health.

Common Conditions Linked to Abnormal Results

Low alpha-1 antitrypsin levels are strongly linked to alpha-1 antitrypsin deficiency, which can cause lung diseases (e.g., emphysema) or liver diseases (e.g., cirrhosis). High levels may be associated with conditions like chronic obstructive pulmonary disease (COPD) or certain inflammatory states.