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COVID-19 IgG Antibody to SARS-CoV-2 (Serum) – Mass Concentration

Published: August 9, 2026Updated: August 16, 2026

This test measures the presence of IgG antibodies in your serum that your immune system produces in response to exposure to the virus that causes COVID-19. IgG antibodies help your body fight off infections and provide long-term immunity.

Quick summary

["This test helps determine if you’ve had prior exposure to COVID-19 and may have developed immunity."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
27406-8
Short code
Deprecated S pneum19f IgG Ser-mCnc
Synonyms
Deprecated S pneum19f IgG Ser-mCnc
Category
coagulation
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Does This Test Measure?

IgG antibodies are a type of protein your immune system makes after encountering the COVID-19 virus. These antibodies are part of your body’s defense system and can remain in your blood for months or even years after infection. This test specifically looks for IgG antibodies against the spike protein of the SARS-CoV-2 virus, which is responsible for causing COVID-19. The result indicates whether your immune system has recognized and responded to the virus.

Why Might You Need This Test?

Healthcare providers may recommend this test if you have had COVID-19 symptoms, have been exposed to someone with COVID-19, or if you are recovering from a COVID-19 infection. It can also be used for screening in certain settings, such as before returning to work or travel, or for monitoring immunity in high-risk groups.

How Is This Test Performed?

A blood sample is drawn from a vein in your arm. The serum portion of the blood is then tested in a laboratory using an immunoassay method to detect the presence of IgG antibodies. The test does not measure the current viral load or active infection but rather past exposure.

What Are the Possible Results?

A positive result means your blood contains IgG antibodies to SARS-CoV-2, suggesting you likely had COVID-19 at some point and may have developed immunity. A negative result means no detectable IgG antibodies were found, indicating either no prior exposure or insufficient time since exposure for antibodies to develop. Results should be interpreted by a healthcare provider in the context of your medical history and symptoms.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

COVID-19 IgG Antibody Test

Frequently asked questions

How long do IgG antibodies last after COVID-19?
IgG antibodies typically remain in your system for several months to years after infection, but their exact duration varies from person to person. Some studies suggest they may persist for at least six months, while others indicate they can remain detectable for longer periods. Your healthcare provider can discuss the relevance of these antibodies in your specific situation.
Can this test be used to confirm a current COVID-19 infection?
No, this test measures antibodies produced after infection, not the virus itself. For diagnosing an active COVID-19 infection, tests like PCR or rapid antigen tests are used instead.
Does having IgG antibodies mean I’m immune to COVID-19?
Having IgG antibodies suggests you’ve had some level of immunity from past infection, but immunity can vary. New variants of the virus may still pose a risk, and healthcare providers may recommend additional precautions or booster shots based on your health status and vaccination history.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy