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Total Immunoglobulin G (IgG) in Serum

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of Immunoglobulin G (IgG), a type of antibody in your blood. IgG helps protect your body from infections and diseases.

Quick summary

["IgG antibodies play a key role in long-term immunity and are often checked if you have concerns about immune function or recurrent infections."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
40965-6
Short code
Deprecated S pneum20 IgG Ser-mCnc
Synonyms
Deprecated S pneum20 IgG Ser-mCnc
Category
coagulation
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Does IgG Measure?

IgG is the most abundant antibody in your blood, produced by your immune system to fight off bacteria and viruses. It helps remember past infections and provides protection against future exposures. Levels can vary based on your immune health, age, and overall health status.

Why Might Your Doctor Order This Test?

Your doctor may order an IgG test if you have symptoms like frequent infections, unexplained illnesses, or if you’re being evaluated for conditions like HIV, autoimmune diseases, or immune deficiencies. It can also be part of routine monitoring for certain treatments.

How Is the Test Performed?

A blood sample is drawn from a vein, usually in your arm. The blood is then sent to a lab where it is tested for IgG levels using an immunoassay method, which detects the presence and concentration of antibodies.

What Are Common Results?

Results are typically reported as a concentration in grams per liter (g/L) or milligrams per deciliter (mg/dL). While reference ranges can vary by lab, lower than expected levels may suggest immune system issues, while higher levels might indicate chronic infections or other conditions.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

IgG Level

Frequently asked questions

Why might my IgG levels be checked regularly?
Regular IgG monitoring may be recommended if you have a history of immune-related conditions, such as HIV, lupus, or other autoimmune diseases. It can help track how well your immune system is responding to treatment or managing chronic health issues.
What does it mean if my IgG levels are low?
Low IgG levels can indicate an immune deficiency, where your body struggles to produce enough antibodies to fight infections. This might require further evaluation by a healthcare provider to determine the underlying cause and appropriate treatment.
Can diet or lifestyle affect IgG levels?
While diet and lifestyle factors like nutrition and stress can influence overall immune function, IgG levels are primarily determined by your body’s immune response. Changes in diet may indirectly support immune health but won’t directly alter IgG test results.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy