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Total IgG Antibody to Streptococcus pneumoniae (Serum)

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of antibodies in your blood that target the bacteria *Streptococcus pneumoniae*, which can cause serious infections like pneumonia, meningitis, or bloodstream infections.

Quick summary

["This test helps assess your immune response to pneumococcal bacteria, often used in monitoring vaccination effectiveness or diagnosing immune-related conditions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
47337-1
Short code
Deprecated S pneum22 IgG sp2 Ser IA-mCnc
Synonyms
Deprecated S pneum22 IgG sp2 Ser IA-mCnc
Category
coagulation
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ia
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you’ve had or are at risk for pneumococcal infections, especially if you’ve received the pneumococcal vaccine. It may also be used to evaluate immune function in people with weakened immune systems or chronic illnesses.

What to Expect Before the Test

No special preparation is needed. You’ll provide a blood sample, usually drawn from a vein in your arm. The blood will be sent to a lab for analysis.

What the Results Mean

Higher-than-normal levels may indicate an active immune response to pneumococcal bacteria, while very low levels could suggest a weakened immune response or prior vaccination history. Results are interpreted by your healthcare provider in the context of your medical history.

Common Reasons for Testing

This test is often used to monitor the effectiveness of pneumococcal vaccines, check for immune deficiencies, or evaluate the body’s response to infections caused by *Streptococcus pneumoniae*.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

IgG Anti-Pneumococcal Antibody

Frequently asked questions

What does a positive result mean?
A positive result (detectable IgG antibodies) suggests your body has produced antibodies against *Streptococcus pneumoniae*, which may indicate prior infection, vaccination, or both. However, this does not confirm active infection and should be interpreted by your provider.
How often should I get this test?
The frequency depends on your health status, vaccination history, and risk factors. Your healthcare provider will determine if repeat testing is needed, such as after vaccination or if you have an ongoing immune-related condition.
Can I eat or drink before this test?
No special diet or fasting is required for this blood test. You may eat and drink normally as usual, unless instructed otherwise by your provider.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy