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Alpha-1 Antitrypsin (Serum) Mass Concentration

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of Alpha-1 Antitrypsin, a protein produced by the liver that helps protect the lungs and other organs from damage caused by enzymes released during inflammation.

Quick summary

["Alpha-1 Antitrypsin levels can help identify genetic conditions affecting lung or liver health."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
26917-5
Short code
Deprecated S pneum23 Ab Ser-mCnc
Synonyms
Deprecated S pneum23 Ab Ser-mCnc
Category
coagulation
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms like chronic cough, shortness of breath, or liver issues, or if you have a family history of Alpha-1 Antitrypsin deficiency—a genetic condition that can lead to lung disease or liver problems over time.

What to Expect During the Test

A small blood sample will be drawn from a vein in your arm. The sample is sent to a lab for analysis. You can eat and drink normally before the test, but let your provider know about any medications you’re taking.

Possible Results and Next Steps

Results are compared to a standard range to determine if your Alpha-1 Antitrypsin levels are low, normal, or high. Low levels may indicate a genetic condition requiring further evaluation, including genetic testing.

Common Conditions Linked to Abnormal Results

Low levels of Alpha-1 Antitrypsin are most strongly associated with Alpha-1 Antitrypsin deficiency, which can cause chronic obstructive pulmonary disease (COPD) or liver cirrhosis. High levels may be seen in certain inflammatory conditions or liver diseases but are less common.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Alpha-1 Antitrypsin (Serum)

Frequently asked questions

What does an abnormal Alpha-1 Antitrypsin result mean?
An abnormal result—particularly low levels—may suggest a genetic condition that requires further genetic testing or evaluation by a specialist. Your provider will discuss next steps based on your symptoms and family history.
How often should I get this test?
If you have a known Alpha-1 Antitrypsin deficiency, your provider may recommend regular testing to monitor your levels. If this is a one-time screening, follow-up may depend on your symptoms and provider’s assessment.
Can diet or exercise affect Alpha-1 Antitrypsin levels?
Diet and exercise generally do not directly alter Alpha-1 Antitrypsin levels, but managing conditions like chronic lung disease through lifestyle changes can improve overall health and quality of life.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy