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Serum Protein Electrophoresis (Qualitative)

Published: August 9, 2026Updated: August 16, 2026

This test measures the different types of proteins in your blood, separated by size and charge, to help identify abnormalities like infections, inflammation, or certain blood disorders.

Quick summary

["This test helps diagnose and monitor conditions affecting protein balance in your blood."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
27138-7
Short code
Deprecated S pneum23 Ab sp1 Ser-mCnc
Synonyms
Deprecated S pneum23 Ab sp1 Ser-mCnc
Category
coagulation
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What This Test Measures

Electrophoresis separates blood proteins into fractions (e.g., albumin, alpha-globulins, beta-globulins, gamma-globulins) based on their electrical charge and size. This helps detect conditions like multiple myeloma, liver disease, or immune disorders.

Why It’s Ordered

Your healthcare provider may order this test if you have symptoms like unexplained weight loss, fatigue, swelling, or if they suspect conditions such as monoclonal gammopathy, liver dysfunction, or chronic inflammation.

Preparation

No special preparation is needed, but avoid alcohol and certain medications (e.g., steroids) for 24 hours before testing if instructed by your provider.

Sample Collection

A blood sample is drawn from a vein in your arm. The serum (liquid part of blood after clotting) is then analyzed in a lab.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Protein Electrophoresis

Frequently asked questions

What Conditions Might Be Detected?
Abnormal patterns in protein electrophoresis can reveal conditions like multiple myeloma (excess monoclonal proteins), liver disease (reduced albumin), or immune disorders (elevated gamma-globulins). It may also help monitor treatment responses.
How Long Does It Take to Get Results?
Results are typically available within 24–48 hours, depending on lab processing times. Follow up with your provider to discuss findings.
Do I Need to Fast Before This Test?
No fasting is required, but check with your provider if you’re on medications that could affect protein levels.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy