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IgG Substance Concentration in Serum (Qualitative or Screening)

Published: August 9, 2026Updated: August 16, 2026

This test measures the presence or level of Immunoglobulin G (IgG), a type of antibody in your blood. IgG is important for long-term immunity.

Quick summary

["IgG helps protect your body from infections and diseases over time."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
22548-2
Short code
Deprecated S pneum23 IgG Ser-aCnc
Synonyms
Deprecated S pneum23 IgG Ser-aCnc
Category
coagulation
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What IgG Testing Measures

IgG is the most abundant antibody in your blood and plays a key role in defending against bacteria and viruses. This test helps determine if your immune system is producing enough IgG, which is crucial for fighting infections long-term. It may be used to check for immune deficiencies, monitor treatment responses, or evaluate immune responses in certain conditions.

Why You Might Need This Test

A healthcare provider may recommend this test if you have symptoms of a weakened immune system, such as frequent infections, recurrent illnesses, or if you’re being treated for an immune-related condition. It can also be part of a broader evaluation for conditions like HIV, autoimmune diseases, or congenital immune disorders.

Sample Collection and Preparation

A blood sample is drawn from a vein, usually in your arm. The blood is then processed to separate the serum (the liquid part without clots). This serum is tested for IgG levels or presence.

Test Results and Interpretation

Results are typically reported as qualitative (positive/negative) or quantitative (levels of IgG). A qualitative test tells if IgG is present, while a quantitative test provides a specific measurement. Interpretation depends on clinical context, such as your medical history and symptoms.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Low IgG levels may indicate an immune deficiency, where your body struggles to fight infections effectively. High levels might be seen in chronic infections, certain autoimmune diseases, or as a side effect of some treatments. This test helps guide treatment plans and monitor immune health over time.

Short name

IgG Screening (Serum)

Frequently asked questions

What does a positive or negative result mean?
A positive or negative result simply indicates whether IgG antibodies are detected in your serum. It does not provide a specific number or range, as reference values can vary by lab and clinical situation. Your healthcare provider will discuss what these results mean for your health.
How often should I get this test?
The frequency depends on your medical condition and treatment plan. Some people need this test regularly to monitor their immune response, while others may only need it once or as part of a specific evaluation. Follow your healthcare provider’s instructions.
Can diet or lifestyle affect IgG levels?
Diet and lifestyle factors like nutrition, stress, and overall health can influence immune function, but they do not directly affect IgG levels measured in this test. Maintaining a balanced diet and good health supports your immune system overall.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy