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Immunoglobulin G (IgG) in Serum – Mass Concentration

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of Immunoglobulin G (IgG), a type of antibody in your blood. IgG is the most common antibody in the body and plays a key role in protecting against infections.

Quick summary

["IgG helps fight infections and supports long-term immunity."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
30494-9
Short code
Deprecated S pneum23 IgG sp1 Ser-mCnc
Synonyms
Deprecated S pneum23 IgG sp1 Ser-mCnc
Category
coagulation
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Does This Test Measure?

IgG is the primary antibody produced by your immune system in response to infections, vaccines, and other immune challenges. It circulates in your bloodstream and provides broad protection against pathogens like bacteria and viruses. This test helps assess your overall immune function and identify potential deficiencies.

Why Might You Need This Test?

Doctors may order an IgG test if you have symptoms of a weakened immune system, such as frequent infections, slow wound healing, or recurrent illnesses. It can also be used to monitor immune responses after treatments like chemotherapy or bone marrow transplants.

What to Expect Before the Test

No special preparation is needed for this blood test. You may have a small needle inserted into your arm to draw a blood sample. If you’re nervous, let your healthcare provider know—they can help make the process more comfortable.

What to Expect After the Test

After the blood is drawn, you may feel a slight pinch or bruising at the site. Apply gentle pressure to stop any bleeding. Most people return to normal activities immediately. If you experience excessive bruising or pain, contact your provider.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Low IgG levels may indicate an immune deficiency, such as common variable immunodeficiency (CVID) or other congenital or acquired immune disorders. High IgG levels can sometimes signal chronic infections, autoimmune conditions, or certain cancers. Monitoring IgG helps guide treatment decisions for immune-related conditions.

Short name

IgG Level

Frequently asked questions

What causes low IgG levels?
Low IgG levels can result from immune system disorders, such as primary immunodeficiency diseases, chronic illnesses like HIV/AIDS, or conditions that affect the body’s ability to produce antibodies, such as certain cancers or long-term use of immunosuppressive medications.
What are the symptoms of low IgG?
Symptoms of low IgG may include frequent or severe infections (e.g., sinusitis, pneumonia, or skin infections), slow healing of wounds, and recurrent ear or respiratory infections. Some people may also experience fatigue or unexplained weight loss.
How is IgG tested?
IgG is measured through a simple blood draw. The blood sample is sent to a lab where it is analyzed using an immunoassay method to determine the precise concentration of IgG antibodies in your serum.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy