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Alpha-1 Antitrypsin (Serum) Quantitative

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of Alpha-1 Antitrypsin, a protein produced mainly by the liver that helps protect the lungs from damage caused by enzymes released during inflammation.

Quick summary

["Alpha-1 Antitrypsin levels help assess lung or liver health, especially in conditions like emphysema or chronic liver disease."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
31640-6
Short code
Deprecated S pneum3 Ab Ser-aCnc
Synonyms
Deprecated S pneum3 Ab Ser-aCnc
Category
coagulation
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms like persistent coughing, shortness of breath, or liver-related issues, or if you have a family history of conditions like Alpha-1 Antitrypsin deficiency. It may also be used to monitor lung or liver function in certain chronic illnesses.

What to Expect During the Test

A blood sample will be drawn from a vein, usually in your arm. You may feel a slight pinch, but it typically takes only a few minutes. No special preparation is usually needed, but let your provider know if you’re on blood-thinning medications.

Common Conditions Monitored

Low levels of Alpha-1 Antitrypsin can contribute to lung diseases like emphysema or chronic obstructive pulmonary disease (COPD). It may also play a role in liver diseases such as cirrhosis. This test helps diagnose or monitor these conditions.

What the Results Mean

Results are interpreted by your healthcare provider based on your medical history and symptoms. Very low levels may indicate a genetic deficiency, while higher levels might be seen in certain liver diseases or infections.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Alpha-1 Antitrypsin (Serum)

Frequently asked questions

How often will I need this test?
The frequency depends on your health condition and treatment plan. If you have a known deficiency, your provider may order this test regularly to monitor your levels and lung/liver health. If it’s part of a routine checkup, it may be done less often.
What happens if my results are low?
Low results may signal a deficiency, prompting further genetic testing or lifestyle adjustments. Your provider will discuss next steps, which could include monitoring, enzyme replacement therapy, or managing symptoms related to lung or liver issues.
Can diet or supplements affect this test?
Dietary changes or supplements are unlikely to impact Alpha-1 Antitrypsin levels directly. However, if you’re on medications (like blood thinners), let your provider know before the test to avoid complications.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy