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Serum Protein Electrophoresis (Qualitative)

Published: August 9, 2026Updated: August 16, 2026

This test measures the types and amounts of proteins in your blood, helping identify abnormalities in protein distribution that may signal conditions like infections, liver disease, or immune disorders.

Quick summary

["This test helps doctors diagnose and monitor conditions affecting protein levels in your blood."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
13141-7
Short code
Deprecated S pneum3 Ab sp1 Ser-aCnc
Synonyms
Deprecated S pneum3 Ab sp1 Ser-aCnc
Category
coagulation
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Proteins Are Measured?

Electrophoresis separates blood proteins into fractions based on size and electrical charge. Key bands include albumin, alpha-globulins, beta-globulins, and gamma-globulins. Abnormal patterns may indicate conditions like multiple myeloma, cirrhosis, or chronic inflammation.

How Is the Test Performed?

A small blood sample is drawn, and the serum is placed in an electric field. Proteins migrate toward the opposite charge, creating distinct bands visible under light. No fasting is required.

Why Might You Need This Test?

Doctors use this test to evaluate symptoms like unexplained weight loss, fatigue, swelling, or unexplained proteinuria. It’s also used to monitor conditions like kidney disease, liver disease, or autoimmune disorders.

What Could Abnormal Results Indicate?

Abnormal bands or shifts may suggest conditions like monoclonal gammopathy (e.g., multiple myeloma), hypoalbuminemia, or increased acute-phase proteins (e.g., CRP). Always discuss results with your healthcare provider.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

This test plays a critical role in identifying underlying causes of systemic symptoms, guiding treatment decisions for conditions affecting protein metabolism or immune function. Results may prompt further testing (e.g., bone marrow biopsy, liver function tests).

Short name

Serum Protein Electrophoresis

Frequently asked questions

Why was this test marked as deprecated?
The test may no longer be routinely used in some clinical settings due to advancements in more specific diagnostic tools or changes in healthcare guidelines. Your doctor will explain its relevance to your care plan.
How long does it take to get results?
Results are typically available within 24–48 hours, depending on lab processing times. Follow-up with your healthcare provider for interpretation.
Can I eat or drink before this test?
No special preparation is needed. However, inform your doctor about any medications or supplements you’re taking, as they may affect results.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy