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Antibody to Streptococcus pneumoniae (Serum) – Qualitative

Published: August 9, 2026Updated: August 16, 2026

This test checks if your body has produced antibodies against the bacteria *Streptococcus pneumoniae*, which can cause serious infections like pneumonia, meningitis, or bloodstream infections.

Quick summary

["It helps determine if you’ve been exposed to or infected by *Streptococcus pneumoniae* bacteria."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
31651-3
Short code
Deprecated S pneum6a+6b Ab Ser-aCnc
Synonyms
Deprecated S pneum6a+6b Ab Ser-aCnc
Category
coagulation
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Matters

This test is often used to diagnose infections caused by *Streptococcus pneumoniae* in people who may have weakened immune systems, chronic health conditions, or are at higher risk of severe complications. It can also be part of screening for certain conditions where exposure to this bacteria is a concern.

How the Test Works

A small blood sample is taken from your arm. The lab analyzes your serum (liquid part of blood without blood cells) to detect the presence of antibodies specific to *Streptococcus pneumoniae*. This is done through an immunoassay method, which identifies these antibodies by their reaction to the bacteria’s antigens.

What to Expect Before the Test

There are no special preparations needed for this test. You may have a slight bruise or soreness at the injection site, but this usually goes away quickly. If you’re on blood-thinning medication, let your healthcare provider know before the test.

What the Results Mean

A positive result means your body has detected antibodies against *Streptococcus pneumoniae*, indicating past exposure or infection. A negative result suggests you either haven’t been exposed or your immune system hasn’t produced these antibodies at detectable levels. Results are qualitative, meaning they only indicate presence or absence, not the exact amount.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Strep Pneumonia Antibody Test

Frequently asked questions

What does a positive result mean?
A positive result suggests you may have had an infection caused by *Streptococcus pneumoniae* in the past or are currently immune due to exposure. This can be useful for diagnosing past infections or assessing immunity in certain populations, such as those who received pneumococcal vaccines.
What does a negative result mean?
A negative result means your body either hasn’t encountered *Streptococcus pneumoniae* or hasn’t produced detectable antibodies against it. This could mean you are not currently infected but may need further evaluation if you have symptoms of pneumonia or other infections.
Can this test be used to diagnose an active infection?
No, this test is qualitative and primarily used to assess past exposure or immunity rather than diagnose an active infection. For diagnosing current infections, other tests like blood cultures or chest X-rays may be needed.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy