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Bilirubin, Total (Serum)

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of bilirubin in your blood. Bilirubin is a yellow pigment produced when red blood cells break down. It’s normally processed by the liver and excreted in bile.

Quick summary

["Your liver’s ability to process bilirubin may be affected by conditions like liver disease or bile duct blockages."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
17637-0
Short code
Deprecated S pneum6b Ab sp2 Ser-aCnc
Synonyms
Deprecated S pneum6b Ab sp2 Ser-aCnc
Category
coagulation
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Doctors may order this test to check for liver problems, such as hepatitis, cirrhosis, or bile duct issues. It can also help diagnose conditions like Gilbert’s syndrome or hemolytic anemia, where red blood cells break down too quickly.

What to Expect Before the Test

No special preparation is needed. You may have a small needle inserted into a vein in your arm to draw blood. Tell your doctor if you’re on blood thinners or have a history of bleeding easily.

What the Results Mean

Higher than normal levels may suggest liver disease, bile duct problems, or red blood cell disorders. Lower levels are less common but could indicate liver disease or certain genetic conditions.

Common Conditions Linked to Results

Elevated bilirubin can signal liver inflammation, blockages in the bile ducts, or increased red blood cell destruction. Low levels are rare but may be seen in liver disease or certain genetic disorders.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Total Serum Bilirubin

Frequently asked questions

Will my bilirubin test affect my medications?
Some medications, like certain antibiotics or pain relievers, may interact with liver function, indirectly affecting bilirubin levels. Always discuss all medications with your doctor before testing.
Can I eat or drink before this test?
You can eat and drink normally unless instructed otherwise. Avoid alcohol for 24 hours before testing, as it may affect liver function and bilirubin levels.
What if my bilirubin is high?
If your bilirubin is elevated, your doctor may recommend further tests, such as liver function tests or imaging, to find the cause. Treatment depends on the underlying condition, which could include medications, lifestyle changes, or surgery.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy