Alpha-1 Antitrypsin (Serum) Concentration
This test measures the level of Alpha-1 Antitrypsin, a protein produced by the liver that helps protect the lungs from damage caused by enzymes released during inflammation.
["A1AT levels can help diagnose or monitor conditions affecting the lungs or liver."]
Key facts at a glance
- LOINC
- 22554-0
- Short code
- Deprecated S pneum7f Ab sp2 Ser-aCnc
- Synonyms
- Deprecated S pneum7f Ab sp2 Ser-aCnc
- Category
- coagulation
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
Why This Test Might Be Ordered
Your healthcare provider may recommend this test if you have symptoms like chronic cough, shortness of breath, or liver issues such as jaundice, fatigue, or abdominal pain. It may also be used to check for genetic conditions like Alpha-1 Antitrypsin Deficiency, which can lead to lung diseases like emphysema or liver diseases over time.
What to Expect During the Test
A blood sample will be taken from a vein in your arm. You may feel a slight pinch, but it usually doesn’t cause discomfort. The sample is then sent to a lab for analysis.
What the Results Mean
Lower than expected levels of Alpha-1 Antitrypsin might indicate a genetic deficiency or liver disease. Higher levels may be seen in certain inflammatory conditions or during pregnancy. Your results will be compared to standard reference ranges provided by your healthcare provider.
Common Conditions Monitored
This test is often used to monitor individuals with a known history of Alpha-1 Antitrypsin Deficiency, chronic obstructive pulmonary disease (COPD), or liver diseases such as cirrhosis.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Alpha-1 Antitrypsin Deficiency is a genetic disorder that can lead to lung diseases like emphysema and liver diseases. Low levels of A1AT can indicate these conditions, prompting further evaluation and management. Regular monitoring of A1AT levels is crucial for patients with known deficiency to prevent complications and guide treatment decisions.
Short name
Alpha-1 Antitrypsin (A1AT)
Frequently asked questions
What does an abnormal A1AT level indicate?
How often should I get this test?
Can diet or lifestyle changes affect A1AT levels?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy