Serum Anti-Smooth Muscle Antibody (ASMA) Test
This test measures the presence of antibodies against smooth muscle proteins, often used to diagnose autoimmune conditions affecting organs like the liver, lungs, or heart.
["ASMA antibodies may indicate certain autoimmune diseases requiring further evaluation."]
Key facts at a glance
- LOINC
- 17644-6
- Short code
- Deprecated S pneum9 Ab 1:2 Ser IA-Rto
- Synonyms
- Deprecated S pneum9 Ab 1:2 Ser IA-Rto
- Category
- coagulation
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Ref low
- 200
- Ref high
- 900
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- ia
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
What Is This Test Measuring?
The test detects antibodies (ASMA) that target proteins found in smooth muscle tissues, which are present in organs such as the liver, lungs, and heart. These antibodies can signal an immune response against these tissues, often linked to autoimmune disorders like autoimmune hepatitis or systemic sclerosis.
Why Might You Need This Test?
Your healthcare provider may order this test if you have symptoms like unexplained liver issues (e.g., jaundice, fatigue), lung problems, or signs of connective tissue diseases. It helps assess whether your symptoms could be caused by an autoimmune reaction targeting smooth muscle cells.
How Is the Test Performed?
A blood sample is drawn from a vein in your arm. The serum (liquid part of blood after clotting) is then tested in a lab using an immunoassay method to detect ASMA antibodies.
What Are Possible Results?
Results are qualitative (positive/negative) or semi-quantitative, indicating whether ASMA antibodies are present. A positive result suggests a higher likelihood of an autoimmune condition, but further testing is needed for diagnosis.
Reference range
NCBI: Vitamin B12 200-900 pg/mLN/A
No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
◆Associated findings1
Short name
ASMA Antibody
Frequently asked questions
What does a positive ASMA antibody test mean?
How long does it take to get results?
Can lifestyle changes affect ASMA antibody levels?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy