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Alpha-1 Antitrypsin (A1AT) Serum Concentration (Qualitative)

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of Alpha-1 Antitrypsin, a protein produced by the liver that helps protect the lungs and other organs from damage caused by enzymes released during inflammation or injury.

Quick summary

["A1AT levels help assess risk for lung diseases like emphysema or chronic obstructive pulmonary disease (COPD)."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
22557-3
Short code
Deprecated S pneum9 Ab Ser Ql
Synonyms
Deprecated S pneum9 Ab Ser Ql
Category
coagulation
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have a family history of lung diseases, symptoms like chronic coughing or shortness of breath, or if you have conditions like cirrhosis or liver disease. It may also be used to monitor treatment progress or screen for genetic disorders affecting A1AT production.

What to Expect Before the Test

No special preparation is needed for this test. You may have a small needle inserted into your arm to draw blood. If you’re concerned about needles, let your healthcare provider know. Avoid alcohol for 24 hours before testing if instructed, as it may affect results.

What the Results Mean

Results are qualitative (qualitative means they describe a category rather than a specific number). Low levels of A1AT may indicate an increased risk for lung disease or other health issues. High levels might suggest liver disease or other conditions. Your healthcare provider will interpret the results in the context of your overall health and medical history.

Common Reasons for Testing

This test is often used to diagnose or monitor conditions like Alpha-1 Antitrypsin Deficiency, a genetic disorder that can lead to lung and liver problems. It may also be part of a broader evaluation for chronic lung diseases or to check for liver disease.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

A1AT Screening (Serum)

Frequently asked questions

What are the normal ranges for this test?
Normal ranges for qualitative tests like this are not strictly defined by a single number. Instead, results are categorized as low, normal, or high based on clinical judgment and comparison to your baseline or family history. Your healthcare provider will discuss the results with you and explain what they mean for your health.
Can I eat or drink anything before this test?
For this test, you can eat and drink normally unless your healthcare provider gives specific instructions. Avoid alcohol for 24 hours before testing if advised, as it can sometimes affect blood test results.
How long will it take to get my results?
Results for this qualitative test are typically available within a few days to a week, depending on your lab’s processing time. Your healthcare provider will contact you once the results are ready to discuss them further.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy