Alpha-1 Antitrypsin (A1AT) Serum Concentration (Qualitative)
This test measures the level of Alpha-1 Antitrypsin, a protein produced by the liver that helps protect the lungs and other organs from damage caused by enzymes released during inflammation or injury.
["A1AT levels help assess risk for lung diseases like emphysema or chronic obstructive pulmonary disease (COPD)."]
Key facts at a glance
- LOINC
- 22557-3
- Short code
- Deprecated S pneum9 Ab Ser Ql
- Synonyms
- Deprecated S pneum9 Ab Ser Ql
- Category
- coagulation
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
Why This Test Might Be Ordered
Your healthcare provider may recommend this test if you have a family history of lung diseases, symptoms like chronic coughing or shortness of breath, or if you have conditions like cirrhosis or liver disease. It may also be used to monitor treatment progress or screen for genetic disorders affecting A1AT production.
What to Expect Before the Test
No special preparation is needed for this test. You may have a small needle inserted into your arm to draw blood. If you’re concerned about needles, let your healthcare provider know. Avoid alcohol for 24 hours before testing if instructed, as it may affect results.
What the Results Mean
Results are qualitative (qualitative means they describe a category rather than a specific number). Low levels of A1AT may indicate an increased risk for lung disease or other health issues. High levels might suggest liver disease or other conditions. Your healthcare provider will interpret the results in the context of your overall health and medical history.
Common Reasons for Testing
This test is often used to diagnose or monitor conditions like Alpha-1 Antitrypsin Deficiency, a genetic disorder that can lead to lung and liver problems. It may also be part of a broader evaluation for chronic lung diseases or to check for liver disease.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
◆Associated findings1
Short name
A1AT Screening (Serum)
Frequently asked questions
What are the normal ranges for this test?
Can I eat or drink anything before this test?
How long will it take to get my results?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy