Cerebrospinal Fluid (CSF) Protein Content (Qualitative/Quantitative Analysis)
This test measures the amount of protein in your cerebrospinal fluid, which is the fluid surrounding your brain and spinal cord. It helps assess conditions affecting the central nervous system.
["Protein levels in CSF can signal potential neurological issues or infections."]
Key facts at a glance
- LOINC
- 29319-1
- Short code
- Deprecated S pneumB Ag CSF Ql LA
- Synonyms
- Deprecated S pneumB Ag CSF Ql LA
- Category
- coagulation
- Sample
- csf
- Container
- Sterile tube
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- la
- Specimen volume
- 1-2 mL
- Stability
- Immediate analysis required, Refrigerated: 1h
- Hemolysis max
- 200
- TAT
- 4–24 hours
- Order
- routine
What Is Cerebrospinal Fluid (CSF)?
Cerebrospinal fluid (CSF) is a clear, watery fluid that cushions your brain and spinal cord. It circulates nutrients and removes waste, but it can also carry proteins produced by cells in the central nervous system. When protein levels are abnormal, it may indicate inflammation, bleeding, or other neurological problems.
Why Is This Test Done?
Your doctor may order this test to investigate symptoms like headaches, seizures, numbness, or vision changes. It’s often used alongside imaging (like MRI) or other tests to diagnose conditions such as meningitis, brain tumors, or multiple sclerosis.
How Is the Test Performed?
A small amount of CSF is collected through a procedure called a lumbar puncture (spinal tap). A needle is inserted into your lower back, and fluid is drawn into a vial for testing. The test is usually quick and done in a hospital or clinic.
What Are Common Findings?
High protein levels in CSF can occur with infections (e.g., meningitis), autoimmune diseases, or tumors. Low or normal levels are more common in healthy individuals or those with non-inflammatory conditions. Results are compared to your doctor’s clinical judgment, not strict numeric ranges.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Elevated CSF protein is often a red flag for serious conditions, such as demyelinating diseases (e.g., multiple sclerosis), brain infections, or metastatic cancer. Low protein may suggest normal pressure or benign causes, but further evaluation is needed to rule out underlying issues.
Short name
CSF Protein Test
Frequently asked questions
How long does it take to get results?
What if my protein levels are abnormal?
Can I eat or drink before the test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy