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Total Protein in Serum

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of protein found in your blood serum. Proteins are essential for many bodily functions, including transporting nutrients, maintaining fluid balance, and supporting immune responses.

Quick summary

["Your blood protein levels help doctors assess overall health and detect potential issues like dehydration, liver disease, or kidney problems."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
38059-2
Short code
Deprecated Talus CT
Synonyms
Deprecated Talus CT
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ct
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why It’s Done

Healthcare providers may order this test to evaluate symptoms such as swelling (edema), unexplained weight changes, fatigue, or signs of organ dysfunction. It can also be part of routine check-ups or investigations for conditions like malnutrition, infections, or chronic diseases.

What to Expect Before the Test

No special preparation is usually needed, but you may be asked to fast for 8–12 hours before the test if it’s part of a broader metabolic or liver evaluation. Bring any medications you’re taking to your appointment.

During the Test

A small needle is inserted into a vein in your arm, and blood is drawn into a test tube. The process takes a few minutes, and you may feel a brief pinch. The sample is then sent to a lab for analysis.

Possible Results and Interpretation

Results are expressed in grams per deciliter (g/dL). Low protein levels may indicate conditions like malnutrition, liver disease, or kidney problems, while very high levels could suggest dehydration, inflammation, or certain cancers. Your doctor will discuss findings in the context of your health.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Abnormal protein levels can signal underlying health issues. Low protein levels may reflect poor nutrient absorption, liver or kidney disease, or severe infections. High protein levels could indicate dehydration, severe burns, or certain inflammatory conditions. Regular monitoring helps manage chronic diseases like diabetes or kidney disorders.

Short name

Serum Protein Level

Frequently asked questions

What causes low protein levels?
Low protein levels can result from conditions like liver disease (e.g., cirrhosis), kidney disease, severe infections, or malnutrition. It may also occur if your body loses protein through wounds, vomiting, or diarrhea. Lifestyle factors like poor diet or excessive alcohol use can also contribute.
What causes high protein levels?
High protein levels may be due to dehydration, severe burns, or certain cancers. Inflammation or infections can also temporarily spike protein levels. Rarely, genetic disorders or certain medications may play a role.
Can diet affect protein test results?
Yes, diet can influence protein levels. Eating a balanced diet rich in protein (from lean meats, dairy, legumes, and whole grains) helps maintain normal levels. Avoiding excessive alcohol or poor nutrition may help stabilize results.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy