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Total Serum Immunoglobulin E (IgE) Screening Test

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of Immunoglobulin E (IgE), a protein in your blood that your immune system produces in response to allergens.

Quick summary

["IgE levels help identify potential allergic reactions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
23796-6
Short code
Deprecated Tree Allerg Mix1 IgE Ql
Synonyms
Deprecated Tree Allerg Mix1 IgE Ql
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
multidisk
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Does This Test Measure?

IgE is a type of antibody your body makes when it reacts to substances it perceives as harmful, such as pollen, dust mites, or certain foods. This test checks the overall level of IgE in your serum to help determine if you may have allergies or an allergic reaction.

Why Might You Need This Test?

Your healthcare provider may order this test if you have symptoms like sneezing, itching, skin rashes, or breathing difficulties that suggest allergies. It can also be used as part of an allergy screening before exposure to known allergens or before certain treatments.

How Is the Test Performed?

A blood sample is taken from a vein in your arm. The sample is then sent to a lab where it is analyzed to measure the total IgE concentration.

What Do My Results Mean?

Results are not provided with specific reference ranges in this generic format. Your healthcare provider will interpret the results in the context of your symptoms and medical history to determine if further testing or treatment is needed.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

IgE Screening

Frequently asked questions

What Are Common Causes of Abnormal Results?
Elevated IgE levels can be caused by allergies (e.g., to pollen, pet dander, or foods), asthma, certain infections, or autoimmune conditions. Other factors, such as chronic stress or certain medications, may also influence IgE production.
Can IgE Levels Change Over Time?
Yes, IgE levels can fluctuate depending on exposure to allergens, underlying health conditions, and treatments. For example, allergy medications or avoiding known triggers may reduce IgE levels over time. Always discuss any changes in your results with your healthcare provider.
Is This Test Painful or Discomforting?
The blood draw itself may cause a slight pinch or discomfort, but it usually resolves quickly. Most people experience minimal discomfort afterward. If you have a hard time with blood draws, let your healthcare provider know so they can take extra precautions.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy