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Total Serum Immunoglobulin G (IgG) with Allergen-Specific IgE Screening

Published: August 9, 2026Updated: August 16, 2026

This test measures your body’s immune response by checking both total IgG antibodies and specific IgE antibodies to common allergens. It helps identify if you may have an allergic reaction to certain substances.

Quick summary

["Assesses immune sensitivity to allergens and total antibody levels in your blood."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
24134-9
Short code
Deprecated Tree Allerg Mix6 IgE Ql
Synonyms
Deprecated Tree Allerg Mix6 IgE Ql
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
multidisk
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What This Test Measures

The test includes two key parts: measuring your total IgG levels (a type of antibody that provides long-term immunity) and screening for IgE antibodies to specific allergens. IgE antibodies are linked to allergic reactions, and this screening helps determine if you might react to foods, pollens, pets, or other common triggers.

Why It’s Done

Your healthcare provider may recommend this test if you suspect allergies, have unexplained symptoms like hives, asthma, or digestive issues, or if you’ve had previous allergic reactions. It can also help guide allergy testing or treatment plans.

How the Test Works

A blood sample is drawn from your arm and sent to a lab. The serum (liquid part of blood) is analyzed to detect IgG antibodies (general immune response) and IgE antibodies to specific allergens (potential triggers). Results are interpreted by a healthcare professional.

Preparation and Results

No special preparation is needed, but fasting may be advised depending on the lab’s protocol. Results may take several days to a week to process. Your doctor will discuss findings and next steps, such as allergy testing or avoidance strategies.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

IgG/IgE Mix Screen (Serum)

Frequently asked questions

What does a high or low IgG level or IgE presence mean?
High IgG levels can indicate past infections, chronic immune responses, or certain autoimmune conditions. Elevated IgE to specific allergens suggests a heightened allergic reaction risk to those substances. Low IgG may signal weakened immunity, but this isn’t always linked to allergies.
How long do results stay valid?
IgG levels and IgE antibody responses can change over time due to infections, treatments, or exposure to allergens. Results are specific to the time of testing and should be interpreted with recent medical history in mind.
Can this test replace allergy skin tests?
No. This test provides indirect evidence of IgE exposure but isn’t a direct confirmation of allergy sensitivity. Skin tests (like prick tests) or blood tests (like specific IgE assays) may be needed for a definitive diagnosis.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy