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Total Protein (Serum)

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of protein in your blood serum, which includes important proteins like albumin and globulins that help maintain fluid balance, support immunity, and transport nutrients.

Quick summary

["Your blood protein levels can indicate overall health, hydration status, or potential medical conditions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
5954-3
Short code
Deprecated TT PPP Qn
Synonyms
Deprecated TT PPP Qn
Category
chemistry
Sample
plasma
Container
Lavender-top (EDTA) or Green-top (Heparin)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
tilt-tube
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Doctors may order a total protein test to check for conditions like kidney disease, liver problems, malnutrition, or certain immune disorders. It can also help monitor treatment progress for conditions like multiple myeloma or chronic infections.

What to Expect Before the Test

No special preparation is usually needed, but you may be asked to fast for 8–12 hours before the test if your doctor specifies it. Bring any medications you’re currently taking, as some may affect results.

During the Test

A healthcare provider will draw blood from a vein in your arm using a small needle. You may feel a brief pinch, but the procedure is quick and typically painless. You can usually return to normal activities immediately afterward.

Possible Results and Their Meaning

Results are interpreted based on your overall health and medical history. Low protein levels may suggest malnutrition, liver or kidney disease, or excessive fluid loss. High levels could indicate dehydration, inflammation, or certain cancers.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Total Protein

Frequently asked questions

What causes low total protein levels?
Low protein levels can result from conditions like malnutrition, severe kidney disease, liver failure, or chronic infections. It may also occur due to excessive protein loss (e.g., from kidney disease) or poor absorption of nutrients.
What does it mean if my protein levels are high?
Elevated protein levels can indicate dehydration, inflammation, or certain cancers (like multiple myeloma). Rarely, it may also suggest conditions like multiple myeloma or other blood disorders. Your doctor will review your symptoms and medical history to clarify.
Do medications affect total protein test results?
Yes, some medications (e.g., steroids, chemotherapy drugs, or diuretics) can influence protein levels. If you’re on long-term medication, mention it to your doctor before the test to ensure accurate results.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy