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Total Protein (Serum)

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of protein in your blood serum, which includes albumin and globulin proteins essential for health.

Quick summary

["Total protein helps assess overall protein balance and potential nutritional or liver issues."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
13621-8
Short code
Deprecated TT Qn
Synonyms
Deprecated TT Qn
Category
chemistry
Sample
plasma
Container
Lavender-top (EDTA) or Green-top (Heparin)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
coag
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your doctor may order a total protein test to check for conditions like malnutrition, liver disease, kidney problems, or certain immune disorders. It can also help monitor treatment effectiveness for conditions affecting protein levels.

What Does a Low or High Result Mean?

Low total protein levels might indicate poor nutrition, liver or kidney disease, or excessive protein loss (e.g., from kidney problems). High levels could suggest conditions like multiple myeloma, dehydration, or certain liver diseases.

How Is This Test Performed?

A blood sample is drawn from a vein in your arm. The serum portion is separated and analyzed for protein content using standard laboratory techniques.

What Are Common Causes of Abnormal Results?

Abnormal results can stem from dietary factors, chronic diseases, or medical conditions affecting protein synthesis, breakdown, or excretion.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Total Protein

Frequently asked questions

What if my test results are out of range?
If your results are outside the expected range, your doctor will discuss potential causes with you and may recommend further testing or adjustments to your treatment plan.
How often should I get this test?
Frequency depends on your health condition and doctor’s recommendations. Some people need it yearly, while others may need it more often if managing chronic health issues.
Can diet affect my total protein test results?
Yes, diet can influence protein levels. High-protein diets or deficiencies may temporarily alter results, so it’s best to follow your doctor’s advice regarding timing and preparation.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy