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Vitamin D Binding Protein (DBP) Antibody, Serum

Published: August 9, 2026Updated: August 16, 2026

This test measures antibodies against vitamin D binding protein, a protein that helps transport vitamin D in your blood. These antibodies may indicate an autoimmune response.

Quick summary

["This test helps evaluate potential autoimmune conditions affecting vitamin D metabolism."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
45119-5
Short code
Deprecated VSIV 1 Ab Titr Ser Nt
Synonyms
Deprecated VSIV 1 Ab Titr Ser Nt
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
neut
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms or conditions linked to autoimmune disorders, such as vitamin D resistance syndromes or unexplained metabolic issues. It could also be part of a broader evaluation for conditions like nephrogenic secondary hyperparathyroidism or certain skin disorders.

What to Expect Before the Test

No special preparation is typically needed. You may have a small needle inserted into your arm to draw blood. If you’re on blood thinners or have bleeding disorders, let your provider know beforehand.

What the Test Results Mean

Results are qualitative (positive/negative) and indicate whether your body is producing antibodies against vitamin D binding protein. A positive result suggests an autoimmune reaction, but it doesn’t diagnose a specific condition alone.

Common Conditions Monitored

This test is often used alongside other tests to diagnose or monitor autoimmune-related vitamin D disorders, such as hypovitaminosis D with resistance or certain skin conditions like erythroderma.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Elevated antibody levels may signal an immune system misfiring against vitamin D binding protein, potentially disrupting normal vitamin D function. While not definitive, this finding prompts further investigation into metabolic or autoimmune conditions.

Short name

DBP Antibody (Serum)

Frequently asked questions

What does a positive result mean?
A positive result means your immune system is producing antibodies against vitamin D binding protein, which may suggest an autoimmune response. This doesn’t confirm a specific diagnosis but could guide further testing.
Can this test be used to diagnose vitamin D deficiency?
No, this test does not measure vitamin D levels directly. It’s used to detect antibodies related to vitamin D binding protein, not deficiency itself. A vitamin D level test would be needed for that.
How often should I get this test?
Your provider will determine frequency based on your symptoms, medical history, and other test results. Follow-up may be needed if autoimmune concerns are suspected.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy