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Serum/Plasma Depression Screening Level (Qualitative)

Published: August 9, 2026Updated: August 16, 2026

This test may be used as part of a general screening to help assess whether you might be experiencing symptoms of depression.

Quick summary

["A simple screening tool to check for possible depression; results do not diagnose depression alone."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
28378-8
Short code
DEPRESSION
Synonyms
—
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
reported-hiv-ssc
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What This Test Measures

This test evaluates a qualitative measure of depression-related biomarkers in serum or plasma. It does not measure a single specific chemical but rather uses a standardized approach to screen for potential depressive symptoms. Results are interpreted in the context of clinical evaluation, patient history, and symptoms reported by you or your healthcare provider.

How the Test Is Taken

A small blood sample is drawn from a vein, typically in your arm, by a healthcare professional. The sample is then processed and sent to a lab for analysis.

What to Expect Before the Test

No special preparation is needed for this screening. You may eat and drink normally before the test. If you are on blood-thinning medications, let your healthcare provider know before the procedure.

What to Expect After the Test

You may feel slight discomfort or bruising at the injection site, which usually fades within a few days. Avoid heavy lifting or strenuous activity for a short time to prevent excessive bleeding.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Depression Screening

Frequently asked questions

What does a positive screening result mean?
A positive screening result indicates that your test may show signs consistent with depression, but it does not confirm a diagnosis. It serves as a signal to discuss your symptoms with a healthcare provider who can provide a thorough evaluation and appropriate care.
Can this test be used to monitor depression over time?
No, this test is primarily a screening tool and is not designed for monitoring depression. Ongoing assessment and treatment decisions should be made by a healthcare provider based on clinical judgment, patient feedback, and other relevant factors.
Are there any risks or side effects associated with this blood test?
The most common side effect is mild discomfort or bruising at the injection site. Rarely, there may be a slight swelling or bleeding. Serious complications are very rare and depend on individual health conditions.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy