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Desmoglein 1 Immunoglobulin G (IgG) Antibody in Serum

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of antibodies against desmoglein 1, a protein found in the skin and mucous membranes. These antibodies are linked to autoimmune blistering skin conditions.

Quick summary

["This test helps diagnose or monitor autoimmune blistering disorders like pemphigus vulgaris."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
94335-7
Short code
Desmoglein 1+3 IgG Pnl Ser IA
Synonyms
Desmoglein 1+3 IgG Pnl Ser IA
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ia
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your doctor may order this test if you have symptoms of blistering skin conditions, such as painful sores on the skin or mucous membranes (like the mouth or eyes). It’s also used to confirm a diagnosis of autoimmune blistering diseases or to check how your treatment is working.

What to Expect Before the Test

No special preparation is needed. You’ll provide a blood sample, usually drawn from a vein in your arm. The blood is collected in a tube and sent to the lab for testing.

What the Test Results Mean

High levels of desmoglein 1 antibodies may indicate an autoimmune condition like pemphigus. However, normal results don’t rule out other possible causes of blistering. Your doctor will interpret the results in the context of your symptoms and medical history.

Possible Causes and Conditions

Elevated antibody levels are most strongly associated with pemphigus vulgaris, a rare autoimmune disorder causing painful blisters. Other blistering conditions (like bullous pemphigoid) may have different antibody targets, so this test is specific to desmoglein 1.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

This test plays a key role in diagnosing pemphigus vulgaris by detecting the presence of IgG antibodies that attack desmoglein 1. Early detection can guide treatment decisions, such as immunosuppressive therapies, to reduce blistering and improve quality of life. It’s also used to monitor disease activity and response to treatment over time.

Short name

Desmoglein 1 IgG Antibody

Frequently asked questions

What does a positive result mean?
A positive result (meaning detectable antibodies) strongly suggests pemphigus vulgaris or another related autoimmune blistering disorder. However, your doctor will confirm the diagnosis based on clinical findings, skin biopsies, and other tests. False positives are rare but possible in rare cases.
Can this test be used to diagnose other skin conditions?
No, this test specifically measures antibodies against desmoglein 1, which is linked only to pemphigus-related disorders. Other blistering conditions (like bullous pemphigoid) involve different proteins and would require different antibody tests.
How often should I get this test?
Your doctor will determine the frequency based on your symptoms, diagnosis, and treatment plan. For example, if you’re being treated for pemphigus, follow-up tests may be done every few months to check for changes in antibody levels or disease activity.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy