Desmoglein 1 Immunoglobulin G (IgG) in Serum
This test measures the level of Immunoglobulin G (IgG) antibodies against desmoglein 1, a protein found in the skin and mucous membranes. It is often used to help diagnose or monitor autoimmune blistering skin conditions.
["This test helps assess potential autoimmune blistering disorders by detecting specific antibodies targeting skin proteins."]
Key facts at a glance
- LOINC
- 94336-5
- Short code
- Desmoglein 1 IgG Ser IA-aCnc
- Synonyms
- Desmoglein 1 IgG Ser IA-aCnc
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- ia
- CPT
- 82784
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
Why This Test Might Be Ordered
Your healthcare provider may recommend this test if you have symptoms like blistering, peeling skin, or mouth ulcers that could suggest conditions like pemphigus vulgaris or other autoimmune blistering diseases. It may also be used to monitor disease activity or response to treatment in certain cases.
What to Expect Before the Test
No special preparation is needed for this blood test. You may have a small needle inserted into your arm to draw a blood sample. If you are concerned about needles or have a blood disorder, let your healthcare provider know.
What the Test Results Mean
Higher than expected levels of desmoglein 1 IgG antibodies may indicate an autoimmune response targeting this protein, potentially linked to blistering skin conditions. Results are interpreted by your healthcare provider in the context of your symptoms and medical history.
Common Conditions Monitored
This test is primarily used to diagnose or evaluate autoimmune blistering skin diseases, such as pemphigus vulgaris or other related conditions. It is not a general screening test for other health issues.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Desmoglein 1 IgG antibodies are associated with autoimmune blistering disorders, where the immune system mistakenly attacks proteins in the skin. Elevated levels can suggest conditions like pemphigus, leading to skin blistering, pain, and potential complications. Your provider will use these results alongside clinical findings to guide diagnosis and treatment decisions.
Short name
Desmoglein 1 IgG
Frequently asked questions
What causes abnormal results in this test?
How are test results interpreted?
Can lifestyle changes affect this test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy