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Desmoglein 3 Immunoglobulin G (IgG) Antibody in Serum

Published: August 9, 2026Updated: August 16, 2026

This test measures antibodies to desmoglein 3, a protein found in the skin and mucous membranes. It helps diagnose and monitor autoimmune blistering skin conditions.

Quick summary

["This test may help identify conditions like pemphigus, an autoimmune disorder causing skin blistering."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
94337-3
Short code
Desmoglein 3 IgG Ser IA-aCnc
Synonyms
Desmoglein 3 IgG Ser IA-aCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ia
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may order this test if you have symptoms like blistering or peeling skin, mouth sores, or a history of autoimmune diseases. It helps determine whether your condition is related to antibodies attacking desmoglein 3, a key protein in skin layers.

What to Expect During the Test

A blood sample is taken from a vein in your arm. You may feel a small pinch when the needle is inserted, but the process usually takes less than five minutes. No special preparation is needed.

What the Results Mean

High levels of desmoglein 3 antibodies may indicate an autoimmune blistering disorder. Your results will be reviewed by a healthcare provider to assess your symptoms and overall health. They may also compare your results to others for context.

Common Conditions Linked to This Test

This test is primarily used to diagnose or confirm conditions like pemphigus vulgaris or pemphigus foliaceus, which involve the immune system attacking skin proteins, including desmoglein 3.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Desmoglein 3 IgG Antibody

Frequently asked questions

What are the normal ranges for this test?
There are no standard reference ranges provided for this test because they can vary by lab and patient context. Your results will be interpreted by your healthcare provider based on your symptoms and clinical picture.
Can this test be done at home?
No, this test requires a blood sample collected by a healthcare professional in a clinical setting.
How long does it take to get results from this test?
Results are typically available within 1 to 3 business days, depending on the lab and your healthcare provider’s workflow.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy