Farnesoid X Receptor (FXR) Activity/Function (Serum)
This test measures the activity of Farnesoid X Receptor (FXR), a protein involved in regulating bile acid metabolism and liver function. It may be used to assess liver health or bile flow in certain conditions.
["This test helps evaluate how well your liver processes bile acids and may support diagnosis of liver or gallbladder disorders."]
Key facts at a glance
- LOINC
- 7277-7
- Short code
- D farinae BasoBnd Ab Qn
- Synonyms
- D farinae BasoBnd Ab Qn
- Category
- chemistry
- Sample
- whole-blood
- Container
- Lavender-top (EDTA)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- lhr
- Specimen volume
- 3 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h
- Hemolysis max
- 0
- Lipemia max
- 0
- Icterus max
- 0
- TAT
- 4–24 hours
- Order
- routine
What This Test Measures
FXR activity is assessed through its influence on bile acid metabolism. Elevated or altered FXR activity can indicate changes in liver function or bile flow, which may be linked to conditions like primary biliary cholangitis or other metabolic liver diseases.
Why It Might Be Ordered
Your healthcare provider may recommend this test if you have symptoms like itching, fatigue, or liver-related issues, or if you have conditions known to affect bile acid metabolism. It can also be part of a broader evaluation for liver disease or metabolic disorders.
Sample Collection and Preparation
A blood sample is drawn from a vein, typically in your arm. The serum portion of the blood is used for this test. You may be asked to fast for a certain period before the test, depending on your provider’s instructions.
What to Expect Before the Test
No special preparation is typically required beyond standard blood draw precautions. If you’re on medications that affect liver function, let your provider know to avoid potential interactions.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Changes in FXR activity can reflect underlying liver or bile duct issues. High or low activity may signal conditions affecting bile acid processing, such as liver inflammation, gallbladder disease, or metabolic syndrome. This test is less commonly used than others but may be critical in specialized cases.
Short name
FXR Activity Test
Frequently asked questions
What does an abnormal result mean?
Is fasting required for this test?
How long does it take to get results?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy