Farnesoid X Receptor (FXR) Activity in Bile Acid Metabolite Concentration (Serum/Plasma)
This test measures the levels of bile acids that interact with the Farnesoid X Receptor, a protein involved in regulating bile acid metabolism and liver function.
["Assesses how bile acids influence liver health and bile flow."]
Key facts at a glance
- LOINC
- 63075-6
- Short code
- D farinae IgG-mCnc
- Synonyms
- D farinae IgG-mCnc
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- CPT
- 82784
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
What This Test Measures
The test detects specific bile acids that bind to the Farnesoid X Receptor (FXR). These bile acids help control processes like bile production, cholesterol, and glucose metabolism in the liver. Changes in these levels may reflect how well your body is processing bile acids or could indicate liver or metabolic conditions.
Why It Might Be Ordered
Your healthcare provider may order this test if you have symptoms or conditions linked to bile acid dysfunction, such as liver disease, gallbladder issues, or metabolic disorders. It could also be part of monitoring for conditions like primary biliary cholangitis or non-alcoholic fatty liver disease.
How the Test Works
Blood is drawn to collect a serum or plasma sample. The test measures the concentration of bile acids that bind to FXR using a specialized analytical method to detect these metabolites.
Preparation for the Test
No special preparation is needed. However, inform your provider if you are taking medications that may affect bile acid levels, such as certain antibiotics or cholesterol-lowering drugs.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Abnormal results may suggest issues with bile acid metabolism, such as liver disease, bile duct blockages, or metabolic syndrome. Elevated or altered bile acid levels could indicate conditions affecting bile flow or liver function, while different patterns might point to specific metabolic or genetic disorders.
Short name
FXR Activity Test
Frequently asked questions
What does a high or low result mean?
Can this test be used to diagnose liver disease?
Does diet affect this test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy