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C-reactive protein (high-sensitivity) concentration, serum/plasma

Published: August 9, 2026Updated: August 16, 2026

This test measures a protein in your blood that rises when your body is fighting inflammation, often used to check for signs of inflammation or infection.

Quick summary

["hsCRP helps track inflammation, aiding in early detection of conditions like heart disease or autoimmune disorders."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
65790-8
Short code
D farinae (nDer f) 1 IgE Qn
Synonyms
D farinae (nDer f) 1 IgE Qn
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
86430
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order this test to monitor chronic conditions like heart disease, rheumatoid arthritis, or other inflammatory diseases. It can also help assess risk for future health issues or guide treatment decisions.

What to Expect Before the Test

No special preparation is needed. You may have a small needle inserted into your arm to draw blood. If you’re on blood thinners, let your provider know before the test.

What the Results Mean

Results are interpreted based on your medical history and symptoms. Higher levels may indicate inflammation, while lower levels suggest reduced risk. Your provider will discuss what your specific result means for you.

Common Conditions Monitored

hsCRP is often used alongside other tests to evaluate risks for cardiovascular disease, infections, or inflammatory conditions like lupus or psoriasis.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: hsCRP serves as a marker for systemic inflammation. Elevated levels may signal underlying conditions requiring further investigation, while normal levels may indicate lower risk. It’s particularly useful in risk stratification for conditions like atherosclerosis or autoimmune diseases.

Short name

hsCRP

Frequently asked questions

What causes my hsCRP levels to change?
Inflammation from infections, injuries, or autoimmune diseases can raise hsCRP levels. Stress, certain medications, or lifestyle factors (like diet or exercise) may also influence results. Repeated testing helps track trends over time.
Can diet or exercise affect hsCRP results?
Yes. Anti-inflammatory diets, regular physical activity, and avoiding smoking can lower hsCRP levels. Temporary spikes may occur after illness or stress, so results should be interpreted in context with your overall health.
Do I need to fast before this test?
No fasting is required for hsCRP. However, if you’re on blood pressure or cholesterol medications, check with your provider to ensure timing aligns with your usual schedule.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy