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Folate (Serum) Concentration

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of folate, a B vitamin, in your blood serum. Folate is important for cell growth and red blood cell production.

Quick summary

["Checks if you have enough folate, which supports your body’s health and prevents certain deficiencies."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
99035-8
Short code
dfrA5 Islt/Spm Ql
Synonyms
dfrA5 Islt/Spm Ql
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
molgen
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms of folate deficiency, such as fatigue, weakness, or unusual bleeding. It’s also used during pregnancy to ensure proper folate levels, as low levels can increase the risk of birth defects. Additionally, it may be checked if you have conditions like anemia, alcohol use, or certain medications that can affect folate levels.

What to Expect Before the Test

No special preparation is usually needed. You may be asked to fast for 8–12 hours before the test if it’s part of a broader metabolic evaluation. Bring any medications you’re taking, as some may influence results.

How the Test Is Performed

A blood sample is drawn from a vein in your arm by a healthcare professional. The blood is then sent to a lab for analysis to measure folate concentration.

What the Results Mean

Results are typically reported as a numerical value (in micrograms per deciliter, µg/dL). Low levels may indicate deficiency, while higher levels could suggest conditions like liver disease or certain medications. Your provider will interpret the results in the context of your overall health.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Serum Folate

Frequently asked questions

Is folate deficiency common?
Yes, folate deficiency can occur due to poor diet, alcohol use, certain medications, or malabsorption issues. Pregnant individuals are often advised to maintain adequate folate levels to support fetal development.
Can folate levels change over time?
Yes, folate levels can fluctuate based on diet, medication use, and underlying health conditions. Regular monitoring may be needed if you have a history of deficiency or related symptoms.
Does folate testing differ between serum and red blood cell levels?
Serum folate measures the vitamin in your blood plasma, while red blood cell folate reflects stored levels. Both can be useful, but serum is often checked for acute deficiency assessment.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy