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Serum Creatinine Concentration (Mass Concentration)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of creatinine, a waste product from muscle metabolism, in your blood serum. It helps assess how well your kidneys are filtering blood.

Quick summary

["Creatinine levels help check kidney function and detect early kidney problems."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
54385-0
Short code
DHA/Vit C SFr SerPl
Synonyms
DHA/Vit C SFr SerPl
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order this test to monitor kidney health, especially if you have symptoms like fatigue, swelling, or changes in urine output. It’s also used before certain procedures, to check for kidney disease, or to evaluate kidney function in people with diabetes or high blood pressure.

What to Expect Before the Test

No special preparation is needed, but you may be asked to fast for 8–12 hours before the test if it’s part of a broader metabolic panel. Drink plenty of water the day before to help your kidneys function normally.

How the Test Is Performed

A blood sample is drawn from a vein, usually in your arm, by a healthcare professional. The serum is then separated and tested for creatinine levels using a specialized laboratory method.

Possible Results and Interpretation

Results are compared to standard reference ranges, though exact values can vary by lab. High levels may suggest kidney problems, while low levels could indicate muscle disorders or other conditions. Your provider will discuss your specific results with you.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Creatinine

Frequently asked questions

What does a high creatinine level mean?
A high creatinine level often indicates reduced kidney function, as creatinine is a waste product filtered by the kidneys. It may signal early kidney disease, dehydration, or conditions like heart failure or severe muscle breakdown. Your provider will assess results alongside other factors like urine output and symptoms.
What does a low creatinine level mean?
Low creatinine levels may suggest poor muscle mass, liver disease, or certain metabolic disorders. However, very low levels can sometimes indicate dehydration or errors in testing. Always discuss results with your healthcare provider.
How often should I get this test?
Your provider will determine the frequency based on your health status, medical history, and any ongoing conditions. Regular monitoring may be recommended if you have kidney disease, diabetes, or other risk factors for kidney problems.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy