Dehydroepiandrosterone sulfate (DHEA-S) in serum/plasma
This test measures the level of dehydroepiandrosterone sulfate (DHEA-S), a hormone produced primarily by the adrenal glands. It reflects your body’s natural production of this hormone, which plays a role in energy levels, immune function, and sex hormone balance.
["DHEA-S levels can offer insights into adrenal health and may be checked for conditions like adrenal insufficiency or hormonal imbalances."]
Key facts at a glance
- LOINC
- 56589-5
- Short code
- DHEA 1.5h p chal SerPl-mCnc
- Synonyms
- DHEA 1.5h p chal SerPl-mCnc
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Ref low
- 135
- Ref high
- 980
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- CPT
- 82626
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
What Is Dehydroepiandrosterone Sulfate (DHEA-S)?
DHEA-S is a sulfurated form of dehydroepiandrosterone (DHEA), a precursor hormone in the adrenal glands. It is one of the most abundant steroid hormones in the human body and serves as an important marker for adrenal function. Your body converts DHEA-S into other hormones, including testosterone and estrogen, which influence metabolism, stress response, and overall vitality.
Why Might Your Doctor Order This Test?
Your doctor may request a DHEA-S test if you have symptoms like chronic fatigue, low libido, muscle weakness, or signs of adrenal dysfunction. It can also be part of evaluations for conditions such as Cushing’s syndrome, Addison’s disease, or hormonal disorders in both men and women.
Sample Collection and Preparation
This test requires a blood sample drawn from a vein in your arm. You may experience a brief pinch or discomfort during the draw, but it usually lasts only a few minutes. Avoid eating or drinking anything for a few hours before the test, as this can affect results.
What to Expect After the Test
After your blood sample is collected, you can return to your normal activities immediately. There are no special instructions for post-test care, but follow-up with your doctor if you have any questions about your results or symptoms.
Reference range
NCBI: DHEA-S Male 135-980 µg/dL; Female 30-260 µg/dLN/A
No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
◆Associated findings1
Short name
DHEA-S
Frequently asked questions
How long does it take to get my DHEA-S results back?
What do low DHEA-S levels mean?
Can lifestyle changes affect DHEA-S test results?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy