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Dehydroepiandrosterone sulfate (DHEA-S) serum concentration

Published: August 9, 2026Updated: August 17, 2026

This test measures the level of dehydroepiandrosterone sulfate (DHEA-S) in your blood, a hormone produced primarily by the adrenal glands. It can help assess adrenal function and hormone balance.

Quick summary

["DHEA-S levels may reflect overall adrenal health and can be useful in certain hormonal evaluations."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
56586-1
Short code
DHEA 15M p chal SerPl-mCnc
Synonyms
DHEA 15M p chal SerPl-mCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
135
Ref high
980
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82626
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Is Dehydroepiandrosterone Sulfate (DHEA-S)?

DHEA-S is a hormone precursor found in the blood, derived from the adrenal glands. It plays a role in producing other hormones, including sex hormones and cortisol. Measuring DHEA-S can provide insight into adrenal gland function and may be part of broader hormone assessments.

Why Might You Need This Test?

A healthcare provider may order a DHEA-S test if you have symptoms or conditions related to hormonal imbalances, such as fatigue, low libido, or adrenal dysfunction. It can also be part of evaluations for conditions like adrenal insufficiency, Cushing’s syndrome, or certain types of cancer.

How Is the Test Performed?

A blood sample is drawn from a vein, usually in your arm. The blood is then sent to a lab for analysis. This test typically requires fasting, but your provider will give specific instructions if needed.

What Do Results Mean?

Results are not provided with specific reference ranges in this summary. Your healthcare provider will interpret the results in the context of your symptoms, medical history, and other test results to determine if levels are within expected ranges or if further action is needed.

Reference range

NCBI: DHEA-S Male 135-980 µg/dL; Female 30-260 µg/dLN/A

Specimen: serum

No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: DHEA-S Levels and Health

Short name

DHEA-S

Frequently asked questions

What factors could affect my DHEA-S test results?
Several factors may influence DHEA-S levels, including age, sex, medications (such as steroids or birth control), stress, and certain medical conditions. For example, DHEA-S levels tend to decline with age. Your provider will consider these factors when reviewing your results.
How often should I get this test?
The frequency of testing depends on your medical needs, symptoms, and ongoing health conditions. Your healthcare provider will determine the best schedule based on your individual situation, such as monitoring adrenal function or evaluating hormonal imbalances.
Can I take anything special before this test?
Yes, your provider may instruct you to fast for 8 to 12 hours before the test or to avoid certain medications. Follow all instructions provided by your healthcare team to ensure accurate results.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy