Dehydroepiandrosterone sulfate (DHEA-S) in serum/plasma
This test measures the level of dehydroepiandrosterone sulfate (DHEA-S), a hormone produced primarily by the adrenal glands. It reflects your body’s natural production of this hormone, which plays a role in energy levels, immune function, and sex hormone balance.
["DHEA-S levels can help assess adrenal gland health and hormone balance."]
Key facts at a glance
- LOINC
- 13863-6
- Short code
- DHEA 1h p 250 ug ACTH SerPl-mCnc
- Synonyms
- DHEA 1h p 250 ug ACTH SerPl-mCnc
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Ref low
- 10
- Ref high
- 60
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- CPT
- 82626
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
Why Might You Need This Test?
Your healthcare provider may order a DHEA-S test to evaluate adrenal function, especially if you have symptoms like fatigue, low sex drive, muscle weakness, or unexplained weight changes. It can also be used in conditions like adrenal insufficiency, Cushing’s syndrome, or to monitor hormone therapy.
What Does a Low or High Level Mean?
Low DHEA-S levels may indicate adrenal gland problems, such as chronic stress, autoimmune disorders, or certain medications affecting hormone production. High levels could suggest adrenal tumors, hyperfunction, or other metabolic conditions. However, results depend on your overall health and medical history.
How Is This Test Done?
A blood sample is drawn from a vein in your arm. The sample is sent to a lab where it is analyzed using a chemiluminescent immunoassay (CLIA) method to measure DHEA-S concentration.
What Should You Expect Before the Test?
No special preparation is usually needed, but you may be asked to avoid certain medications (like steroids) that could affect hormone levels. Fasted or non-fasted blood draws are typically acceptable, but always follow your provider’s instructions.
Reference range
NCBI: ACTH 10-60 pg/mLN/A
Typically collected in the morning (8-10 AM). Inform your provider if taking steroid medications.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Clinical Significance: DHEA-S plays a role in energy metabolism, immune response, and sex hormone production. It is often used as a biomarker for adrenal health, particularly in conditions like Addison’s disease or adrenal fatigue. Elevated levels may also be seen in conditions like Cushing’s syndrome or adrenal adenomas.
Short name
DHEA-S
Frequently asked questions
What causes DHEA-S levels to change?
How long does it take to get results?
Can DHEA-S levels be affected by diet?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy