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Dehydroepiandrosterone sulfate (DHEA-S)

Published: August 9, 2026Updated: August 17, 2026

This test measures the level of dehydroepiandrosterone sulfate (DHEA-S) in your blood, a hormone produced primarily by the adrenal glands. It’s often used to assess adrenal function and hormone balance.

Quick summary

["DHEA-S levels can provide insight into adrenal health and hormone production."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
55475-8
Short code
DHEA 1h p ACTH SerPl-sCnc
Synonyms
DHEA 1h p ACTH SerPl-sCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
10
Ref high
60
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82626
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Might This Test Be Ordered?

Your healthcare provider may recommend a DHEA-S test if you have symptoms like fatigue, low libido, muscle weakness, or unexplained weight changes. It could also be part of evaluations for conditions like adrenal insufficiency, Cushing’s syndrome, or hormonal imbalances.

What Does This Test Measure?

DHEA-S is a sulfate form of dehydroepiandrosterone (DHEA), a precursor hormone in the adrenal glands. It reflects the body’s production of androgens (male hormones) and can be influenced by stress, age, and certain medical conditions.

Sample Collection and Preparation

This test uses a blood sample drawn from a vein in your arm. You may be asked to fast for a few hours before the test, but your provider will give specific instructions. The blood is sent to a lab for analysis using a high-performance liquid chromatography (HPLC) method.

What to Expect Before the Test

No special preparation is typically required beyond avoiding alcohol or certain medications for a few days before testing. If you’re on blood thinners or other medications, let your provider know to avoid interference.

Reference range

NCBI: ACTH 10-60 pg/mLN/A

Specimen: serum

Typically collected in the morning (8-10 AM). Inform your provider if taking steroid medications.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

DHEA-S

Frequently asked questions

What are normal DHEA-S levels?
There are no specific reference ranges provided here since they vary by lab and age. Your results will be interpreted by your healthcare provider in the context of your symptoms and medical history.
How often should I get this test?
Your provider will determine the frequency based on your symptoms, diagnosis, or ongoing health concerns. Routine screening for DHEA-S is not standard unless indicated for specific conditions.
Can lifestyle changes affect DHEA-S levels?
Yes, factors like stress, diet, exercise, and sleep can influence hormone levels. Managing stress, maintaining a balanced diet, and getting adequate rest may support healthy hormone production.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy