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Dehydroepiandrosterone sulfate (DHEA-S) in serum/plasma

Published: August 9, 2026Updated: August 17, 2026

This test measures the sulfate form of dehydroepiandrosterone (DHEA), a hormone produced primarily by the adrenal glands. It reflects your body’s natural hormone production and can be useful in assessing adrenal function or hormonal balance.

Quick summary

["DHEA-S helps evaluate adrenal health and may be checked for conditions like hormonal imbalances or adrenal disorders."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
56510-1
Short code
DHEA 1h p chal SerPl-mCnc
Synonyms
DHEA 1h p chal SerPl-mCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
135
Ref high
980
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82626
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Is DHEA-S Used For?

DHEA-S levels can be measured to help diagnose or monitor conditions linked to adrenal gland function, such as adrenal insufficiency, Cushing’s syndrome, or hormonal disorders. It may also be used in research or clinical settings to assess overall hormone production in adults.

How Is the Test Performed?

A blood sample is drawn from a vein in your arm. The sample is then sent to a lab for analysis using a specialized immunoassay method to measure DHEA-S levels in your serum or plasma.

What Might Affect Your Results?

Several factors could influence DHEA-S levels, including age (levels tend to decline with age), certain medications (like steroids or hormonal treatments), stress, diet, and lifestyle habits. If you’re taking medications or have recent health changes, let your healthcare provider know.

When Might You Need This Test?

Your doctor may recommend a DHEA-S test if you have symptoms like fatigue, weight changes, or hormonal imbalances. It may also be part of a broader evaluation for adrenal disorders, hormonal testing, or research studies.

Reference range

NCBI: DHEA-S Male 135-980 µg/dL; Female 30-260 µg/dLN/A

Specimen: serum

No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

DHEA-S

Frequently asked questions

Why do some people get DHEA-S tests during pregnancy?
DHEA-S is not routinely checked during pregnancy unless there are specific symptoms or concerns about hormonal imbalances, adrenal function, or fetal development. Your doctor may order it if you have symptoms like unexplained fatigue, high blood pressure, or other signs that warrant further testing.
How soon after my blood draw can I expect results?
Results typically take 1–3 business days, depending on lab processing times. Your healthcare provider will contact you once they’re ready, so check in with them if you haven’t heard back within the expected timeframe.
Can I eat or drink anything before this test?
You can eat and drink normally before this test, as it’s a blood draw and doesn’t require fasting. However, if your doctor has specific instructions (like avoiding certain medications), follow those to ensure accurate results.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy