24-Hour Total Dehydroepiandrosterone Sulfate (DHEAS) Urine Collection and Ratio Score

Why This Test Is Done

Your doctor may order a 24-hour urine DHEAS test if they suspect issues with adrenal gland function, such as adrenal insufficiency, hyperandrogenism, or other hormonal imbalances. It can also be part of a broader evaluation for conditions like Cushing’s syndrome or congenital adrenal hyperplasia. This test helps provide a more complete picture of your hormone levels over a full day, rather than just a single blood sample.

What to Expect During the Test

You’ll need to collect all urine for 24 hours, typically starting after your first morning void. Store the urine in a refrigerator or freezer, and bring the entire sample to your lab on the following day. Your doctor or lab technician will guide you through the process to ensure accuracy.

Sample Collection and Preparation

The test involves collecting every drop of urine for a full 24-hour period. This includes waking up in the middle of the night to urinate if needed. The sample is combined into one container, and the total volume is measured. This method helps standardize hormone levels across different times of day.

What the Results Mean

Results from this test are often analyzed as a ratio score or compared to reference ranges for age and sex. While specific reference ranges can vary, abnormal results may indicate whether your adrenal glands are producing too much or too little DHEAS. Your doctor will interpret the results in the context of your overall health and symptoms.