Dehydroepiandrosterone sulfate (DHEA-S) in serum/plasma
This test measures the level of dehydroepiandrosterone sulfate (DHEA-S), a hormone produced mainly by the adrenal glands. It reflects your body’s natural production of this hormone, which plays a role in energy levels, immune function, and hormone balance.
["DHEA-S helps assess adrenal gland health and hormone production."]
Key facts at a glance
- LOINC
- 13864-4
- Short code
- DHEA 30M p 250 ug ACTH SerPl-mCnc
- Synonyms
- DHEA 30M p 250 ug ACTH SerPl-mCnc
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Ref low
- 10
- Ref high
- 60
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- CPT
- 82626
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
What Is DHEA-S Used For?
Doctors may order DHEA-S testing to evaluate adrenal function, especially in conditions like adrenal insufficiency, Cushing’s syndrome, or to monitor hormone-related disorders. It can also be part of a broader evaluation for chronic fatigue, autoimmune diseases, or metabolic issues.
How Is This Test Performed?
A blood sample is taken from a vein in your arm. The blood is then processed to separate serum or plasma, where the DHEA-S hormone is measured using a sensitive laboratory technique, often immunoassay.
What Does a DHEA-S Test Tell You?
While DHEA-S levels can give clues about adrenal health, they are not a standalone diagnostic test. Results may be compared to reference ranges provided by your lab, but they should be interpreted by your healthcare provider in the context of your symptoms and medical history.
When Might You Need This Test?
You might need a DHEA-S test if you have symptoms like fatigue, low energy, or hormonal imbalances. Your doctor may also order it if you have conditions affecting the adrenal glands, such as Addison’s disease or hypercortisolism.
Reference range
NCBI: ACTH 10-60 pg/mLN/A
Typically collected in the morning (8-10 AM). Inform your provider if taking steroid medications.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Clinical Significance: DHEA-S is a marker of adrenal function and can indicate whether the adrenal glands are producing sufficient hormones. Low levels may suggest adrenal insufficiency or other underlying health issues, while elevated levels could be linked to conditions like Cushing’s syndrome or certain tumors. Always consult your healthcare provider for interpretation.
Short name
DHEA-S
Frequently asked questions
Why might my DHEA-S levels be checked regularly?
Can diet or lifestyle affect DHEA-S levels?
What should I do if my DHEA-S test results are abnormal?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy