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Dehydroepiandrosterone sulfate (DHEA-S) in serum/plasma

Published: August 9, 2026Updated: August 17, 2026

This test measures the sulfate form of dehydroepiandrosterone (DHEA), a hormone produced primarily by the adrenal glands. It reflects your body’s natural production of this precursor to other sex hormones.

Quick summary

["DHEA-S helps assess adrenal gland function and hormone balance."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
56587-9
Short code
DHEA 30M p chal SerPl-mCnc
Synonyms
DHEA 30M p chal SerPl-mCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
135
Ref high
980
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82626
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend a DHEA-S test if you have symptoms or conditions linked to hormonal imbalances, such as fatigue, low sex drive, or unexplained weight changes. It can also be part of evaluations for adrenal disorders, autoimmune diseases, or metabolic conditions.

What to Expect During the Test

A blood sample is drawn from a vein in your arm. You may feel a slight pinch, but it usually takes only a few minutes. No special preparation is needed, though fasting may be advised depending on your provider’s instructions.

Possible Results and Interpretation

Results are not provided in absolute numbers here, as reference ranges vary by lab and age. Your provider will interpret the result in relation to your health status and medical history.

Common Reasons for Testing

DHEA-S testing is often used to evaluate adrenal function, monitor conditions like Cushing’s syndrome or Addison’s disease, or assess hormonal changes in aging or chronic illnesses.

Reference range

NCBI: DHEA-S Male 135-980 µg/dL; Female 30-260 µg/dLN/A

Specimen: serum

No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

DHEA-S

Frequently asked questions

How does DHEA-S relate to my overall health?
DHEA-S levels can indicate whether your adrenal glands are functioning properly. Low levels may suggest adrenal insufficiency or other hormonal imbalances, while elevated levels could point to conditions like Cushing’s syndrome or tumors. Your provider will discuss these findings in the context of your symptoms and medical history.
What do my DHEA-S results mean if they’re outside the normal range?
If your results are outside the typical range, it doesn’t necessarily mean you have a problem. Many factors—including age, genetics, and medications—can influence hormone levels. Your provider will work with you to determine if further testing or adjustments are needed.
Can lifestyle changes affect DHEA-S levels?
Yes, lifestyle factors like diet, stress, and exercise can influence hormone production. While you can’t change your DHEA-S levels directly, maintaining a balanced diet, managing stress, and staying physically active may support overall hormonal health.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy