Dehydroepiandrosterone sulfate (DHEA-S) in serum/plasma
This test measures the level of dehydroepiandrosterone sulfate (DHEA-S), a hormone produced by the adrenal glands that plays a role in energy levels, stress response, and sex hormone production.
["DHEA-S helps assess adrenal gland function and hormone balance."]
Key facts at a glance
- LOINC
- 108750-1
- Short code
- DHEA Msmt SerPl
- Synonyms
- DHEA Msmt SerPl
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Ref low
- 135
- Ref high
- 980
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- CPT
- 82626
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
Why Might This Test Be Ordered?
Your healthcare provider may order a DHEA-S test to evaluate adrenal gland health, especially if you have symptoms like fatigue, low libido, or signs of hormonal imbalances. It may also be used in conditions like adrenal insufficiency, Cushing’s syndrome, or to monitor treatment for hormonal disorders.
What Does a Low or High Level Mean?
Low levels of DHEA-S might indicate adrenal gland problems, such as insufficient hormone production. High levels could suggest adrenal tumors or other metabolic conditions, though this is less common. Results are interpreted in the context of your overall health and symptoms.
How Is the Test Performed?
A blood sample is taken from a vein in your arm. The blood is then processed to separate the serum or plasma for testing. The test is typically performed using an immunoassay method to detect DHEA-S levels accurately.
What Are Common Causes of Abnormal Results?
Abnormal DHEA-S levels can result from conditions affecting the adrenal glands (e.g., adrenal tumors, inflammation), genetic factors, medications (like steroids), or chronic stress. Lifestyle factors, such as diet and exercise, may also influence hormone levels.
Reference range
NCBI: DHEA-S Male 135-980 µg/dL; Female 30-260 µg/dLN/A
No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
DHEA-S is a biomarker for adrenal function and can provide insight into overall metabolic health. It is often used in conjunction with other tests to diagnose or monitor conditions related to hormone production, stress responses, or metabolic disorders. However, it is not a standalone diagnostic test for most conditions.
Short name
DHEA-S
Frequently asked questions
What does a DHEA-S test measure?
How often should I get a DHEA-S test?
Can lifestyle changes affect DHEA-S levels?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy