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Dehydroepiandrosterone sulfate (DHEA-S)

Published: August 9, 2026Updated: August 17, 2026

This test measures the level of dehydroepiandrosterone sulfate (DHEA-S) in your blood, a form of the hormone produced by your adrenal glands that plays a role in energy levels, immune function, and sex hormone balance.

Quick summary

["DHEA-S levels can help assess adrenal gland health and hormone balance."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
111213-5
Short code
DHEA Msmt Ur
Synonyms
DHEA Msmt Ur
Category
chemistry
Sample
urine
Container
Sterile urine container
Units
N/A
Ref low
135
Ref high
980
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82626
Specimen volume
10 mL
Stability
Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may order a DHEA-S test to evaluate adrenal function, check for conditions like adrenal insufficiency, or investigate symptoms such as fatigue, low libido, or hormonal imbalances. It can also be used in research or clinical studies involving hormone-related disorders.

What to Expect Before the Test

No special preparation is usually needed for this blood test. You may be asked to fast for 8–12 hours before the draw, but always follow your provider’s instructions. Bring any medications you’re taking, as some may affect results.

How the Test Is Performed

A blood sample is taken from a vein in your arm by a healthcare professional. You may feel a small pinch, but it usually doesn’t cause discomfort. The blood is sent to a lab for analysis.

What the Results Mean

Results are reported in micrograms per deciliter (µg/dL). While reference ranges vary by lab, lower-than-expected levels may indicate adrenal issues, while higher levels could suggest conditions like Cushing’s syndrome or tumors. Your provider will interpret results in the context of your overall health.

Reference range

NCBI: DHEA-S Male 135-980 µg/dL; Female 30-260 µg/dLN/A

Specimen: urine

No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

DHEA-S

Frequently asked questions

What causes DHEA-S levels to change?
DHEA-S levels can fluctuate due to age (typically highest in childhood, declining with age), genetics, stress, certain medications (like corticosteroids), or underlying health conditions such as adrenal tumors or autoimmune disorders. Lifestyle factors like diet, exercise, and sleep may also play a role.
Are there any risks or side effects from this test?
The most common risk is a minor bruise, swelling, or slight pain at the needle site. Rarely, there may be a reaction to the blood draw, such as fainting or dizziness. If you have a history of bleeding disorders or are on blood thinners, let your provider know before the test.
Can diet or supplements affect DHEA-S results?
Some supplements (like licorice root or certain herbal products) or medications (such as birth control pills or steroids) may influence DHEA-S levels. Avoiding alcohol and caffeine for a few hours before the test can help ensure accurate results, but always follow your provider’s guidance.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy