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Dehydroepiandrosterone sulfate (DHEAS)

Published: August 9, 2026Updated: August 17, 2026

This test measures the level of dehydroepiandrosterone sulfate (DHEAS) in your blood, a hormone produced by the adrenal glands that plays a role in sex hormone production and overall health.

Quick summary

["DHEAS helps assess adrenal gland function and hormone balance."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
49888-1
Short code
DHEA-S 1h p ACTH SerPl-mCnc
Synonyms
DHEA-S 1h p ACTH SerPl-mCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
10
Ref high
60
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82626
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend a DHEAS test to evaluate symptoms related to hormonal imbalances, such as fatigue, low libido, or unusual hair growth. It can also be used to diagnose conditions like adrenal insufficiency or to monitor treatment for conditions like Cushing’s syndrome or congenital adrenal hyperplasia.

What to Expect Before the Test

No special preparation is usually needed, but you may be asked to fast for 8–12 hours before the test if your blood is drawn early in the morning. Wear a comfortable shirt for easy access to your arm.

How the Test Is Performed

A healthcare professional will insert a needle into a vein in your arm to collect a blood sample. You may feel a slight pinch, but the procedure is quick and typically painless. The blood sample is then sent to a lab for analysis.

What the Results Mean

Results are not typically provided in absolute numbers, but they help healthcare providers compare your hormone level to what is expected for your age, sex, and overall health. Very high or very low levels may signal underlying health concerns that need further evaluation.

Reference range

NCBI: ACTH 10-60 pg/mLN/A

Specimen: serum

Typically collected in the morning (8-10 AM). Inform your provider if taking steroid medications.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

DHEAS

Frequently asked questions

What Does a Low DHEAS Level Indicate?
A low DHEAS level may suggest adrenal gland problems, such as adrenal insufficiency or autoimmune disorders affecting hormone production. It can also be seen in older adults or those with certain chronic illnesses.
What Does a High DHEAS Level Indicate?
High DHEAS levels can sometimes be linked to conditions like Cushing’s syndrome (excess cortisol) or certain tumors affecting hormone production. However, elevated levels are more commonly found in people without underlying issues, especially in older adults.
How Often Should I Get This Test?
The frequency of DHEAS testing depends on your symptoms, medical history, and treatment plan. Your healthcare provider will determine how often to repeat the test based on your individual needs, such as monitoring chronic conditions or evaluating new symptoms.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy