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Dehydroepiandrosterone sulfate (DHEA-S) in serum/plasma

Published: August 9, 2026Updated: August 17, 2026

This test measures the sulfate form of dehydroepiandrosterone (DHEA), a hormone produced primarily by the adrenal glands. It reflects your body’s natural production of this hormone, which plays a role in energy levels, stress response, and overall hormone balance.

Quick summary

["DHEA-S levels can help assess adrenal gland function and may be checked for conditions like adrenal insufficiency or hormonal imbalances."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
30029-3
Short code
DHEA Sal-aCnc
Synonyms
DHEA Sal-aCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
135
Ref high
980
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82626
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Is DHEA-S Used For?

Doctors may order a DHEA-S test to evaluate adrenal gland health, especially in cases of suspected adrenal disorders, such as Addison’s disease. It can also be used to monitor hormone levels in conditions affecting the adrenal glands or during treatments that influence hormone production.

Why Might Your Doctor Request This Test?

Your doctor might recommend a DHEA-S test if you have symptoms like fatigue, low blood pressure, or unexplained weight loss, which could indicate adrenal insufficiency. It may also be part of a broader evaluation for hormonal imbalances or during certain medical conditions.

How Is the Test Performed?

A blood sample is drawn from a vein in your arm. The sample is then sent to a lab for analysis. The test measures the concentration of DHEA-S in your serum or plasma, which is compared to a reference range to determine your results.

What Are Common Reasons for Abnormal Results?

Low DHEA-S levels may suggest adrenal gland problems, such as insufficient production of hormones. High levels could indicate conditions like Cushing’s syndrome or certain tumors affecting hormone metabolism. Always discuss results with your healthcare provider.

Reference range

NCBI: DHEA-S Male 135-980 µg/dL; Female 30-260 µg/dLN/A

Specimen: serum

No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: DHEA-S Levels and Health

Short name

DHEA-S

Frequently asked questions

What could cause my DHEA-S levels to be low?
Low DHEA-S levels can be caused by adrenal insufficiency (such as Addison’s disease), certain medications, chronic illnesses, or conditions affecting the adrenal glands. It may also occur in older adults or during stress. If you suspect an underlying issue, consult your doctor.
Can DHEA-S levels change with age or lifestyle?
Yes, DHEA-S levels naturally decline with age. Certain lifestyle factors, such as diet, stress, and exercise, may also influence hormone production. However, these factors alone typically don’t cause significant fluctuations unless there’s an underlying health condition.
Do I need to prepare for this test?
No special preparation is usually needed, but avoid heavy meals or alcohol before the blood draw. If you’re on certain medications, inform your healthcare provider beforehand to ensure accurate results.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy